Oxydiacetyl dichloride

Base Information

• Chemical Name: Oxydiacetyl dichloride
• CAS No.: 21062-20-4
• Molecular Formula: C4H4 Cl2 O3
• Molecular Weight: 170.98
• Hs Code.: 2918990090
• European Community (EC) Number: 244-186-3
• UNII: AH3TD62WTX
• DSSTox Substance ID: DTXSID20175289
• Nikkaji Number: J225.389E
• Wikidata: Q83045591
• Mol file: 21062-20-4.mol

Synonyms:21062-20-4;2,2'-Oxydiacetyl chloride;Diglycolyl chloride;Oxydiacetyl dichloride;Acetyl chloride, 2,2'-oxybis-;2-(2-chloro-2-oxoethoxy)acetyl chloride;2,2-OXYDIACETYLCHLORIDE;Diglycolic dichloride;diglycolic acid dichloride;Oxybis(1-chloroethanone);AH3TD62WTX;Diglycolyl chloride, 95%;2,2'-Oxybis[acetyl chloride];LCZC2438;SCHEMBL2262348;DTXSID20175289;EINECS 244-186-3;MFCD00134471;AKOS015899550;2,2'-Oxydiacetyl Chloride, >/=97%;BS-43948;FT-0638083;O0459;D91875;J-013811

Chemical Property of Oxydiacetyl dichloride

Chemical Property:

• Vapor Pressure: 0.0277mmHg at 25°C
• Melting Point: 121-123 °C
• Refractive Index: n20/D 1.473(lit.)
• Boiling Point: 246.1°Cat760mmHg
• Flash Point: 108.4°C
• PSA: 43.37000
• Density: 1.449g/cm³
• LogP: 0.53380
• XLogP3: 1.2
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 4
• Exact Mass: 169.9537494
• Heavy Atom Count: 9
• Complexity: 109

Purity/Quality:

98%,99%, ^*data from raw suppliers

2,2'-Oxydiacetyl Chloride ^*data from reagent suppliers

Safty Information:

• Hazard Codes: C
• Statements: 34
• Safety Statements: 26-27-28-36/37/39-45

MSDS Files:

SDS file from LookChem

Total 1 MSDS from other Authors

Useful:

• Canonical SMILES: C(C(=O)Cl)OCC(=O)Cl
• Uses: Diglycolyl chloride is suitable for use in the synthesis of ply(ether ester). It may be used in the synthesis of:chiral diphenyl substituted polyether-diester compoundsmorpholine dione analog (IMDNQ)salicylic acid (SA)- based diacids

Technology Process of Oxydiacetyl dichloride

There total 3 articles about Oxydiacetyl dichloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

2,2'-oxybis-acetic acid (110-99-6) → diglycolyl chloride (21062-20-4)

Guidance literature:

With oxalyl dichloride; In benzene;

DOI:10.1016/S0040-4039(00)99467-X

Reference yield: 58.5%

diethylene glycol (111-46-6) → diglycolyl chloride (21062-20-4)

Guidance literature:

diethylene glycol; With oxygen;

With thionyl chloride;

DOI:10.1134/S1070428008090236

Reference yield:

→ diglycolyl chloride (21062-20-4)

Guidance literature:

DOI:10.1016/S0040-4020(01)83409-8

upstream raw materials:

2,2'-oxybis-acetic acid

diethylene glycol

Downstream raw materials:

oxydi-acetic acid bis-(4-nitro-phenyl ester)

diglycolic acid dianilide

2,2'-(3-oxa-pentanedioyldioxy)-di-benzoic acid

oxydi-acetic acid bis-(2-nitro-phenyl ester)

Refernces

• 1、 Leopoldo, Marcello,Lacivita, Enza,Colabufo, Nicola A.,Niso, Mauro,Berardi, Francesco,Perrone, Roberto. "Bivalent ligand approach on 4-[2-(3-methoxyphenyl)ethyl]-1-(2-methoxyphenyl)piperazine: Synthesis and binding affinities for 5-HT7 and 5-HT1A receptors". . p. 5316 - 5321. Retrieved 2007.
• 2、 Yadav, Neelam,Chuttani, Krishna,Mishra, Anil K.,Singh, Bachcha. "Synthesis, Characterization, and Preclinical Evaluation of 99mTc-Labeled Macrobicyclic and Tricyclic Chelators as Single Photon Emission Computed Tomography Tracer". . p. 730 - 736. Retrieved 2016.
• 3、 -. "Secondary amine containing ether bond, amido podand ligand, as well as preparation method and application thereof". Paragraph 0146-0150; 0155-0159; 0163-0167; 0171-0175;. . Retrieved 2020/11/23.
• 4、 -. "CYCLIC PEPTIDES MULTIMERS TARGETING α4β7 INTEGRIN". Page/Page column 29; 30. . Retrieved 2018/05/27.