2-fluoro-N-[(1R)-2-hydroxy-1-methylethyl]-4-(5-{(1R)-1-[4-(5-isopropyl-1,2,4-oxadiazol-3-yl)phenoxy]propyl}-1,2,4-oxadiazol-3-yl)benzamide

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Chemical Name:2-fluoro-N-[(1R)-2-hydroxy-1-methylethyl]-4-(5-{(1R)-1-[4-(5-isopropyl-1,2,4-oxadiazol-3-yl)phenoxy]propyl}-1,2,4-oxadiazol-3-yl)benzamide
CAS No.:1263483-45-9
Molecular Formula:C₂₆H₂₈FN₅O₅
Molecular Weight:509.537
Hs Code.:

Synonyms:2-fluoro-N-[(1R)-2-hydroxy-1-methylethyl]-4-(5-{(1R)-1-[4-(5-isopropyl-1,2,4-oxadiazol-3-yl)phenoxy]propyl}-1,2,4-oxadiazol-3-yl)benzamide

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Chemical Property of 2-fluoro-N-[(1R)-2-hydroxy-1-methylethyl]-4-(5-{(1R)-1-[4-(5-isopropyl-1,2,4-oxadiazol-3-yl)phenoxy]propyl}-1,2,4-oxadiazol-3-yl)benzamide

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Technology Process of 2-fluoro-N-[(1R)-2-hydroxy-1-methylethyl]-4-(5-{(1R)-1-[4-(5-isopropyl-1,2,4-oxadiazol-3-yl)phenoxy]propyl}-1,2,4-oxadiazol-3-yl)benzamide

There total 7 articles about 2-fluoro-N-[(1R)-2-hydroxy-1-methylethyl]-4-(5-{(1R)-1-[4-(5-isopropyl-1,2,4-oxadiazol-3-yl)phenoxy]propyl}-1,2,4-oxadiazol-3-yl)benzamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 83.0%

: 35320-23-1
(R)-2-aminopropan-1-ol

: 1263483-76-6
2-Fluoro-4-(5-{(1R)-1-[4-(5-isopropyl-1,2,4-oxadiazol-3-yl)phenoxy]propyl}-1,2,4-oxadiazol-3-yl)benzoic acid

: 1263483-45-9
2-fluoro-N-[(1R)-2-hydroxy-1-methylethyl]-4-(5-{(1R)-1-[4-(5-isopropyl-1,2,4-oxadiazol-3-yl)phenoxy]propyl}-1,2,4-oxadiazol-3-yl)benzamide

Guidance literature:: With benzotriazol-1-ol; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide; In N,N-dimethyl-formamide; at 20 ℃; for 3h;

Reference yield:

: 767-00-0
4-cyanophenol

: 1263483-45-9
2-fluoro-N-[(1R)-2-hydroxy-1-methylethyl]-4-(5-{(1R)-1-[4-(5-isopropyl-1,2,4-oxadiazol-3-yl)phenoxy]propyl}-1,2,4-oxadiazol-3-yl)benzamide

Guidance literature:: Multi-step reaction with 5 steps

1.1: N,N-dimethyl-formamide / 7.5 h / 0 - 100 °C

2.1: sodium hydride / 1,4-dioxane; mineral oil / 0.17 h / 0 - 20 °C

2.2: 4 h / 80 °C

3.1: benzotriazol-1-ol; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide / N,N-dimethyl-formamide / 0.5 h / 20 °C

3.2: 14 h / 100 °C

4.1: trifluoroacetic acid / dichloromethane / 2 h / 20 °C

5.1: benzotriazol-1-ol; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide / N,N-dimethyl-formamide / 3 h / 20 °C

With sodium hydride; benzotriazol-1-ol; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide; trifluoroacetic acid; In 1,4-dioxane; dichloromethane; N,N-dimethyl-formamide; mineral oil;

Reference yield:

: 164149-28-4
4-cyano-2-fluorobenzoic acid

: 1263483-45-9
2-fluoro-N-[(1R)-2-hydroxy-1-methylethyl]-4-(5-{(1R)-1-[4-(5-isopropyl-1,2,4-oxadiazol-3-yl)phenoxy]propyl}-1,2,4-oxadiazol-3-yl)benzamide

Guidance literature:: Multi-step reaction with 5 steps

1.1: tert-butyl alcohol / tetrahydrofuran / 3 h / 60 °C

2.1: hydroxylamine / ethanol; water; tetrahydrofuran / 2 h / 80 °C

3.1: benzotriazol-1-ol; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide / N,N-dimethyl-formamide / 0.5 h / 20 °C

3.2: 14 h / 100 °C

4.1: trifluoroacetic acid / dichloromethane / 2 h / 20 °C

5.1: benzotriazol-1-ol; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide / N,N-dimethyl-formamide / 3 h / 20 °C

With hydroxylamine; benzotriazol-1-ol; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide; trifluoroacetic acid; tert-butyl alcohol; In tetrahydrofuran; ethanol; dichloromethane; water; N,N-dimethyl-formamide;