2'-fluoro-N-(3-fluorobenzyl)-4-(trifluoromethyl)-2,4'-bipyridin-6-amine

Base Information

Chemical Name:2'-fluoro-N-(3-fluorobenzyl)-4-(trifluoromethyl)-2,4'-bipyridin-6-amine
CAS No.:1263374-82-8
Molecular Formula:C₁₈H₁₂F₅N₃
Molecular Weight:365.305
Hs Code.:

Synonyms:2'-fluoro-N-(3-fluorobenzyl)-4-(trifluoromethyl)-2,4'-bipyridin-6-amine

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Chemical Property of 2'-fluoro-N-(3-fluorobenzyl)-4-(trifluoromethyl)-2,4'-bipyridin-6-amine

Chemical Property:

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Technology Process of 2'-fluoro-N-(3-fluorobenzyl)-4-(trifluoromethyl)-2,4'-bipyridin-6-amine

There total 4 articles about 2'-fluoro-N-(3-fluorobenzyl)-4-(trifluoromethyl)-2,4'-bipyridin-6-amine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1263374-80-6
6-chloro-N-(3-fluorobenzyl)-4-(trifluoromethyl)pyridin-2-amine

: 401815-98-3
2-fluoropyridin-4-ylboronic acid

: 1263374-82-8
2'-fluoro-N-(3-fluorobenzyl)-4-(trifluoromethyl)-2,4'-bipyridin-6-amine

Guidance literature:: With sodium carbonate; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; In 1,2-dimethoxyethane; at 105 ℃; for 6h;

Reference yield:

: 6-chloro-N-(3-fluorobenzyl)-4-(trifluoromethyl)pyridin-2-amine trifluoroacetate

: 401815-98-3
2-fluoropyridin-4-ylboronic acid

: 1263374-82-8
2'-fluoro-N-(3-fluorobenzyl)-4-(trifluoromethyl)-2,4'-bipyridin-6-amine

Guidance literature:: With sodium carbonate; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; In 1,2-dimethoxyethane; at 105 ℃; for 6h;

Reference yield:

: 100-82-3
(3-fluorophenyl)methanamine

: 1263374-82-8
2'-fluoro-N-(3-fluorobenzyl)-4-(trifluoromethyl)-2,4'-bipyridin-6-amine

Guidance literature:: Multi-step reaction with 2 steps

1: triethylamine / dimethyl sulfoxide / 1 h / 90 °C

2: sodium carbonate / dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂ / 1,2-dimethoxyethane / 6 h / 105 °C

With sodium carbonate; triethylamine; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; In 1,2-dimethoxyethane; dimethyl sulfoxide; 2: Suzuki Coupling;