(4'S)-1-methyl-1-{2'-[2''-(di-ortho-tolylphosphanyl)-phenyl]-4',5'-dihydrooxazol-4'-yl}-ethyl benzoate

Base Information

Chemical Name:(4'S)-1-methyl-1-{2'-[2''-(di-ortho-tolylphosphanyl)-phenyl]-4',5'-dihydrooxazol-4'-yl}-ethyl benzoate
CAS No.:1313491-70-1
Molecular Formula:C₃₃H₃₂NO₃P
Molecular Weight:521.596
Hs Code.:

Synonyms:(4'S)-1-methyl-1-{2'-[2''-(di-ortho-tolylphosphanyl)-phenyl]-4',5'-dihydrooxazol-4'-yl}-ethyl benzoate

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Chemical Property of (4'S)-1-methyl-1-{2'-[2''-(di-ortho-tolylphosphanyl)-phenyl]-4',5'-dihydrooxazol-4'-yl}-ethyl benzoate

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Technology Process of (4'S)-1-methyl-1-{2'-[2''-(di-ortho-tolylphosphanyl)-phenyl]-4',5'-dihydrooxazol-4'-yl}-ethyl benzoate

There total 7 articles about (4'S)-1-methyl-1-{2'-[2''-(di-ortho-tolylphosphanyl)-phenyl]-4',5'-dihydrooxazol-4'-yl}-ethyl benzoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 86.0%

: 1313491-65-4
(4'S)-2-{2'-[2''-(di-ortho-tolylphosphanyl)-phenyl]-4',5'-dihydrooxazol-4'-yl}-propan-2-ol

: 98-88-4
benzoyl chloride

: 1313491-70-1
(4'S)-1-methyl-1-{2'-[2''-(di-ortho-tolylphosphanyl)-phenyl]-4',5'-dihydrooxazol-4'-yl}-ethyl benzoate

Guidance literature:: (4'S)-2-{2'-[2''-(di-ortho-tolylphosphanyl)-phenyl]-4',5'-dihydrooxazol-4'-yl}-propan-2-ol; With potassium hydride; In tetrahydrofuran; at 0 - 20 ℃; for 2h;

benzoyl chloride; In tetrahydrofuran; at 0 - 20 ℃; for 19h;
DOI:10.1016/j.tet.2011.02.021

Reference yield:

: 29949-64-2
di(o-tolyl)phosphine

: 1313491-70-1
(4'S)-1-methyl-1-{2'-[2''-(di-ortho-tolylphosphanyl)-phenyl]-4',5'-dihydrooxazol-4'-yl}-ethyl benzoate

Guidance literature:: Multi-step reaction with 2 steps

1.1: n-butyllithium / tetrahydrofuran; hexane / 2.5 h / -78 - 0 °C

2.1: potassium hydride / tetrahydrofuran / 2 h / 0 - 20 °C

2.2: 19 h / 0 - 20 °C

With n-butyllithium; potassium hydride; In tetrahydrofuran; hexane;
DOI:10.1016/j.tet.2011.02.021

Reference yield:

: 393-52-2
2-Fluorobenzoyl chloride

: 1313491-70-1
(4'S)-1-methyl-1-{2'-[2''-(di-ortho-tolylphosphanyl)-phenyl]-4',5'-dihydrooxazol-4'-yl}-ethyl benzoate

Guidance literature:: Multi-step reaction with 5 steps

1.1: triethylamine / methanol / 2.5 h / 0 °C

2.1: tetrahydrofuran; diethyl ether / 18 h / 0 - 20 °C

2.2: 0 °C / Saturated solution

3.1: triethylamine; p-toluenesulfonyl chloride / dichloromethane / 75 h / 20 °C

4.1: n-butyllithium / tetrahydrofuran; hexane / 2.5 h / -78 - 0 °C

5.1: potassium hydride / tetrahydrofuran / 2 h / 0 - 20 °C

5.2: 19 h / 0 - 20 °C

With n-butyllithium; potassium hydride; triethylamine; p-toluenesulfonyl chloride; In tetrahydrofuran; methanol; diethyl ether; hexane; dichloromethane;
DOI:10.1016/j.tet.2011.02.021