ethyl 2-amino-3-nitro-6-(4-(2-fluorophenyl)phenyl)pyridine-4-carboxylate

Base Information

Chemical Name:ethyl 2-amino-3-nitro-6-(4-(2-fluorophenyl)phenyl)pyridine-4-carboxylate
CAS No.:168840-02-6
Molecular Formula:C₂₁H₁₈FN₃O₄
Molecular Weight:395.39
Hs Code.:

Synonyms:ethyl 2-amino-3-nitro-6-(4-(2-fluorophenyl)phenyl)pyridine-4-carboxylate

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Chemical Property of ethyl 2-amino-3-nitro-6-(4-(2-fluorophenyl)phenyl)pyridine-4-carboxylate

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Technology Process of ethyl 2-amino-3-nitro-6-(4-(2-fluorophenyl)phenyl)pyridine-4-carboxylate

There total 1 articles about ethyl 2-amino-3-nitro-6-(4-(2-fluorophenyl)phenyl)pyridine-4-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 37989-92-7
1-(2′-fluoro-[1,1′-biphenyl]-4-yl)propan-1-one

: 168840-02-6
ethyl 2-amino-3-nitro-6-(4-(2-fluorophenyl)phenyl)pyridine-4-carboxylate

Guidance literature:: Multi-step reaction with 2 steps

1: 30 percent Spectr_. / (EtO)2Mg / toluene / a) RT, 4 h, b) reflux, 14 h

2: 37 percent / ethanol / 16 h / Heating

With magnesium ethylate; In ethanol; toluene;
DOI:10.1002/jhet.5570320349

Reference yield:

: 168840-02-6
ethyl 2-amino-3-nitro-6-(4-(2-fluorophenyl)phenyl)pyridine-4-carboxylate

: 168840-05-9
ethyl 2,3-diamino-6-(4-(2-fluorophenyl)phenyl)pyridine-4-carboxylate

Guidance literature:: With hydrogen; palladium on activated charcoal; In tetrahydrofuran; for 22h; under 3102.9 Torr; Ambient temperature;
DOI:10.1002/jhet.5570320349

Reference yield:

: 168840-02-6
ethyl 2-amino-3-nitro-6-(4-(2-fluorophenyl)phenyl)pyridine-4-carboxylate

: ethyl 5-(4-(2-fluorophenyl)phenyl)-6-methyl-3H-imidazo<4,5-b>pyridine-7-carboxylate

Guidance literature:: Multi-step reaction with 2 steps

1: 2.37 g / H₂ / 10percent Pd/C / tetrahydrofuran / 22 h / 3102.9 Torr / Ambient temperature

2: 2.) 1 N HCl / 1.) reflux, 6 h, 2.) reflux, 60 min

With hydrogenchloride; hydrogen; palladium on activated charcoal; In tetrahydrofuran;
DOI:10.1002/jhet.5570320349