1-(2'-Fluoro-[1,1'-biphenyl]-4-yl)propan-1-one

Base Information

Chemical Name:1-(2'-Fluoro-[1,1'-biphenyl]-4-yl)propan-1-one
CAS No.:37989-92-7
Molecular Formula:C15H13 F O
Molecular Weight:228.266
Hs Code.:2914700090
European Community (EC) Number:670-935-2
DSSTox Substance ID:DTXSID80372095
Wikidata:Q82159683
Mol file:37989-92-7.mol

Synonyms:37989-92-7;1-(2'-Fluoro-[1,1'-biphenyl]-4-yl)propan-1-one;1-(2'-fluoro[1,1'-biphenyl]-4-yl)propan-1-one;1-[4-(2-fluorophenyl)phenyl]propan-1-one;4-(2-fluorophenyl)propiophenone;1-(2'-Fluoro-biphenyl-4-yl)-1-propanone;4'-(2-Fluorophenyl)Propiophenone;1-{2'-fluoro-[1,1'-biphenyl]-4-yl}propan-1-one;2-Fluoro-4'-propanoylbiphenyl;Maybridge3_006207;1-(2'-Fluoro-[11'-biphenyl]-4-yl)propan-1-one;SCHEMBL1906865;DTXSID80372095;4-(2-fluorophenyl) propiophenone;ZXIQZWXVSBJPTC-UHFFFAOYSA-N;HMS1448K03;BCP21490;CCG-50991;MFCD00236612;AKOS004117028;AB90173;DS-2936;IDI1_017594;1-(2'-fluorobiphenyl-4-yl)propan-1-one;1-[4-(2-fluorophenyl)phenyl]-1-propanone;CS-0152656;FT-0605536;A823957;SR-01000640322-1;129159-23-5

Suppliers and Price of 1-(2'-Fluoro-[1,1'-biphenyl]-4-yl)propan-1-one

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

TRC
1-(2''-Fluoro-[1,1’-biphenyl]-4-yl)propan-1-one
500mg
$ 65.00

TRC
1-(2''-Fluoro-[1,1’-biphenyl]-4-yl)propan-1-one
100mg
$ 45.00

SynQuest Laboratories
4'-(2-Fluorophenyl)propiophenone 97%
10 g
$ 184.00

SynQuest Laboratories
4'-(2-Fluorophenyl)propiophenone 97%
1 g
$ 29.00

Oakwood
4'-(2-Fluorophenyl)propiophenone 98%
5g
$ 125.00

Oakwood
4'-(2-Fluorophenyl)propiophenone 98%
1g
$ 45.00

Oakwood
4'-(2-Fluorophenyl)propiophenone 98%
25g
$ 360.00

Oakwood
4'-(2-Fluorophenyl)propiophenone 98%
100g
$ 1295.00

Crysdot
1-(2'-Fluoro-[1,1'-biphenyl]-4-yl)propan-1-one 98%
25g
$ 391.00

American Custom Chemicals Corporation
1-(2'-FLUORO[1,1'-BIPHENYL]-4-YL)PROPAN-1-ONE 95.00%
10G
$ 1335.18

Total 24 raw suppliers

Chemical Property of 1-(2'-Fluoro-[1,1'-biphenyl]-4-yl)propan-1-one

Chemical Property:

Melting Point:76-77
Boiling Point:334.1°Cat760mmHg
Flash Point:138.5°C
PSA：17.07000
Density:1.102g/cm³
LogP:4.08540
Storage Temp.:Sealed in dry,Room Temperature
XLogP3:3.8
Hydrogen Bond Donor Count:0
Hydrogen Bond Acceptor Count:2
Rotatable Bond Count:3
Exact Mass:228.095043196
Heavy Atom Count:17
Complexity:256

Purity/Quality:

97% ^*data from raw suppliers

1-(2''-Fluoro-[1,1’-biphenyl]-4-yl)propan-1-one ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:
Statements: 36/37/38
Safety Statements: 26-36/37/39

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:CCC(=O)C1=CC=C(C=C1)C2=CC=CC=C2F

Technology Process of 1-(2'-Fluoro-[1,1'-biphenyl]-4-yl)propan-1-one

There total 3 articles about 1-(2'-Fluoro-[1,1'-biphenyl]-4-yl)propan-1-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 32.0%

: 10342-83-3
4'-Bromopropiophenone

: 1993-03-9
o-fluorophenylboronic acid

: 37989-92-7
1-(2′-fluoro-[1,1′-biphenyl]-4-yl)propan-1-one

Guidance literature:: With dipotassium hydrogenphosphate; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In 1,4-dioxane; water; at 130 ℃; for 1.5h; Sealed tube; Inert atmosphere;
DOI:10.1002/chem.201702999

Reference yield:

: C₁₂H₁₈FN₃

: 37989-92-7
1-(2′-fluoro-[1,1′-biphenyl]-4-yl)propan-1-one

Guidance literature:: Multi-step reaction with 2 steps

1: boron trifluoride diethyl etherate / acetonitrile / 0.5 h / 20 °C / Inert atmosphere

2: potassium carbonate; tetrakis(triphenylphosphine) palladium⁽⁰⁾ / 15 h / 90 °C / Inert atmosphere

With tetrakis(triphenylphosphine) palladium⁽⁰⁾; boron trifluoride diethyl etherate; potassium carbonate; In acetonitrile; 2: |Stille Cross Coupling;
DOI:10.1021/acs.joc.8b02766

Reference yield:

: 10342-83-3
4'-Bromopropiophenone

: 2542-07-6
(2-fluorophenyl)trimethylstannane

: 37989-92-7
1-(2′-fluoro-[1,1′-biphenyl]-4-yl)propan-1-one

Guidance literature:: With tetrakis(triphenylphosphine) palladium⁽⁰⁾; potassium carbonate; at 90 ℃; for 15h; Inert atmosphere;
DOI:10.1021/acs.joc.8b02766