(R)-N-<2-(benzyloxacarbonyl)-1-oxoethyl>-3-amino-4-phenyl-N'-(benzyloxy)-N'-methylbutanamide

Base Information

Chemical Name:(R)-N-<2-(benzyloxacarbonyl)-1-oxoethyl>-3-amino-4-phenyl-N'-(benzyloxy)-N'-methylbutanamide
CAS No.:115364-80-2
Molecular Formula:C₂₈H₃₀N₂O₅
Molecular Weight:474.557
Hs Code.:

Synonyms:(R)-N-<2-(benzyloxacarbonyl)-1-oxoethyl>-3-amino-4-phenyl-N'-(benzyloxy)-N'-methylbutanamide

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (R)-N-<2-(benzyloxacarbonyl)-1-oxoethyl>-3-amino-4-phenyl-N'-(benzyloxy)-N'-methylbutanamide

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Technology Process of (R)-N-<2-(benzyloxacarbonyl)-1-oxoethyl>-3-amino-4-phenyl-N'-(benzyloxy)-N'-methylbutanamide

There total 5 articles about (R)-N-<2-(benzyloxacarbonyl)-1-oxoethyl>-3-amino-4-phenyl-N'-(benzyloxy)-N'-methylbutanamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 39.0%

: 40204-26-0
malonic acid monobenzyl ester

: 115364-67-5
(R)-3-amino-4-phenyl-N'-(benzyloxy)butanamide trifluoroacetate

: 115364-80-2
(R)-N-<2-(benzyloxacarbonyl)-1-oxoethyl>-3-amino-4-phenyl-N'-(benzyloxy)-N'-methylbutanamide

Guidance literature:: With 1-hydroxybenzotriazol-hydrate; triethylamine; dicyclohexyl-carbodiimide; In chloroform; 1.) 0 deg C, 1 h, 2.) room temperature, overnight;
DOI:10.1021/jm00117a025

Reference yield:

: 2687-43-6
O-benzylhydoxylamine hydrochloride

: 115364-80-2
(R)-N-<2-(benzyloxacarbonyl)-1-oxoethyl>-3-amino-4-phenyl-N'-(benzyloxy)-N'-methylbutanamide

Guidance literature:: Multi-step reaction with 3 steps

1: 52.4 percent / triethylamine, 1-hydroxybenzotriazole hydrate, dicyclohexylcarbodiimide / CHCl₃ / 1.) 0 deg C, 1 h, 2.) room temperature, overnight

2: 75 percent / CH₂Cl₂ / 1 h / 0 °C

3: 39 percent / triethylamine, 1-hydroxybenzotriazole hydrate, dicyclohexylcarbodiimide / CHCl₃ / 1.) 0 deg C, 1 h, 2.) room temperature, overnight

With 1-hydroxybenzotriazol-hydrate; triethylamine; dicyclohexyl-carbodiimide; In dichloromethane; chloroform;
DOI:10.1021/jm00117a025

Reference yield:

: 101555-61-7
(R)-3-t-butoxycarbonylamino-4-phenylbutyric acid

: 115364-80-2
(R)-N-<2-(benzyloxacarbonyl)-1-oxoethyl>-3-amino-4-phenyl-N'-(benzyloxy)-N'-methylbutanamide

Guidance literature:: Multi-step reaction with 3 steps

1: 52.4 percent / triethylamine, 1-hydroxybenzotriazole hydrate, dicyclohexylcarbodiimide / CHCl₃ / 1.) 0 deg C, 1 h, 2.) room temperature, overnight

2: 75 percent / CH₂Cl₂ / 1 h / 0 °C

3: 39 percent / triethylamine, 1-hydroxybenzotriazole hydrate, dicyclohexylcarbodiimide / CHCl₃ / 1.) 0 deg C, 1 h, 2.) room temperature, overnight

With 1-hydroxybenzotriazol-hydrate; triethylamine; dicyclohexyl-carbodiimide; In dichloromethane; chloroform;
DOI:10.1021/jm00117a025