4-(2-{[(1E)-(4-hydroxyphenyl)methylene]amino}[1,3]thiazolo[4,3-b][1,3,4]thiadiazol-5-yl)phenol

Base Information

• Chemical Name: 4-(2-{[(1E)-(4-hydroxyphenyl)methylene]amino}[1,3]thiazolo[4,3-b][1,3,4]thiadiazol-5-yl)phenol
• CAS No.: 1388811-04-8
• Molecular Formula: C₁₇H₁₃N₃O₂S₂
• Molecular Weight: 355.441
• Mol file: 1388811-04-8.mol

Synonyms:4-(2-{[(1E)-(4-hydroxyphenyl)methylene]amino}[1,3]thiazolo[4,3-b][1,3,4]thiadiazol-5-yl)phenol

Chemical Property of 4-(2-{[(1E)-(4-hydroxyphenyl)methylene]amino}[1,3]thiazolo[4,3-b][1,3,4]thiadiazol-5-yl)phenol

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 4-(2-{[(1E)-(4-hydroxyphenyl)methylene]amino}[1,3]thiazolo[4,3-b][1,3,4]thiadiazol-5-yl)phenol

There total 1 articles about 4-(2-{[(1E)-(4-hydroxyphenyl)methylene]amino}[1,3]thiazolo[4,3-b][1,3,4]thiadiazol-5-yl)phenol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

4-hydroxy-benzaldehyde (123-08-0,65581-83-1) → 4-(2-{[(1E)-(4-hydroxyphenyl)methylene]amino}[1,3]thiazolo[4,3-b][1,3,4]thiadiazol-5-yl)phenol (1388811-04-8)

Guidance literature:

Multi-step reaction with 2 steps

1.2: -20 °C

2.1: sulfuric acid / ethanol / Reflux

With sulfuric acid; In ethanol;

DOI:10.2174/157018012800673038

Reference yield: 75.0%

4-(2-{[(1E)-(4-hydroxyphenyl)methylene]amino}[1,3]thiazolo[4,3-b][1,3,4]thiadiazol-5-yl)phenol (1388811-04-8) + chloroacetyl chloride (79-04-9) → 3-chloro-4-(4-hydroxyphenyl)-1-[5-(4-hydroxyphenyl)[1,3]thiazolo[4,3-b][1,3,4]thiadiazol-2-yl]azetidin-2-one (1388811-24-2)

Guidance literature:

With triethylamine; In 1,4-dioxane; at 0 - 5 ℃; for 3h;

DOI:10.2174/157018012800673038

upstream raw materials:

4-hydroxy-benzaldehyde

Downstream raw materials:

3-chloro-4-(4-hydroxyphenyl)-1-[5-(4-hydroxyphenyl)[1,3]thiazolo[4,3-b][1,3,4]thiadiazol-2-yl]azetidin-2-one