(4-isopropoxy-3-methoxyphenyl)-N,N-dimethylmethanamine

Base Information

Chemical Name:(4-isopropoxy-3-methoxyphenyl)-N,N-dimethylmethanamine
CAS No.:1258935-43-1
Molecular Formula:C₁₃H₂₁NO₂
Molecular Weight:223.315
Hs Code.:

Synonyms:(4-isopropoxy-3-methoxyphenyl)-N,N-dimethylmethanamine

Suppliers and Price of (4-isopropoxy-3-methoxyphenyl)-N,N-dimethylmethanamine

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (4-isopropoxy-3-methoxyphenyl)-N,N-dimethylmethanamine

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Technology Process of (4-isopropoxy-3-methoxyphenyl)-N,N-dimethylmethanamine

There total 1 articles about (4-isopropoxy-3-methoxyphenyl)-N,N-dimethylmethanamine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 82.0%

: 2538-98-9
4-isopropyloxy-3-methoxybenzaldehyde

: 506-59-2
N,N-dimethylammonium chloride

: 1258935-43-1
(4-isopropoxy-3-methoxyphenyl)-N,N-dimethylmethanamine

Guidance literature:: 4-isopropyloxy-3-methoxybenzaldehyde; N,N-dimethylammonium chloride; With titanium(IV) isopropylate; triethylamine; In ethanol; at 30 ℃; for 16h;

With sodium tetrahydroborate; In ethanol; for 14h;
DOI:10.3987/COM-10-12056

Reference yield: 92.0%

: 1258935-43-1
(4-isopropoxy-3-methoxyphenyl)-N,N-dimethylmethanamine

: 79-22-1
methyl chloroformate

: 1260522-86-8
methyl 6-(chloromethyl)-3-isopropoxy-2-methoxybenzoate

Guidance literature:: (4-isopropoxy-3-methoxyphenyl)-N,N-dimethylmethanamine; With n-butyllithium; In tetrahydrofuran; hexane; at -10 ℃; for 1h; Inert atmosphere;

methyl chloroformate; In tetrahydrofuran; hexane; at -78 - 20 ℃; Inert atmosphere;
DOI:10.3987/COM-10-12056

Reference yield:

: 1258935-43-1
(4-isopropoxy-3-methoxyphenyl)-N,N-dimethylmethanamine

: 16562-14-4,66142-83-4,16562-13-3
(-)-stepholidine

Guidance literature:: Multi-step reaction with 13 steps

1.1: n-butyllithium / tetrahydrofuran; hexane / 1 h / -10 °C / Inert atmosphere

1.2: -78 - 20 °C / Inert atmosphere

2.1: palladium 10% on activated carbon; hydrogen / methanol / 8 h / 20 °C / 760.05 Torr

3.1: water / ethanol / 4 h / Reflux

4.1: oxalyl dichloride / 2 h / Reflux

5.1: ammonium hydroxide / diethyl ether / 1 h / 0 - 20 °C

6.1: 1,3,5-trichloro-2,4,6-triazine / N,N-dimethyl-formamide / 16 h / 20 °C

7.1: lithium diisopropyl amide / tetrahydrofuran / 0.5 h / -78 °C / Inert atmosphere

7.2: 0.67 h / -78 - -60 °C / Inert atmosphere

8.1: hydrogenchloride; water / methanol / 2 h / 20 °C

9.1: potassium hydroxide / ethanol; water / 12 h / Reflux

10.1: pyridine / 20 °C

11.1: sodium hydride / tetrahydrofuran; mineral oil / 2 h / 20 °C

12.1: lithium aluminium tetrahydride / tetrahydrofuran / 2 h / Inert atmosphere; Reflux

13.1: boron trichloride / dichloromethane / -78 - 20 °C / Inert atmosphere

With pyridine; hydrogenchloride; ammonium hydroxide; lithium aluminium tetrahydride; n-butyllithium; 1,3,5-trichloro-2,4,6-triazine; oxalyl dichloride; palladium 10% on activated carbon; water; hydrogen; boron trichloride; sodium hydride; potassium hydroxide; lithium diisopropyl amide; In tetrahydrofuran; methanol; diethyl ether; ethanol; hexane; dichloromethane; water; N,N-dimethyl-formamide; mineral oil;
DOI:10.3987/COM-10-12056