tert-butyl 3-(6-(dibenzylamino)-8-oxo-7H-purin-9(8H)-yl)phenyl(methyl)carbamate

Base Information

Chemical Name:tert-butyl 3-(6-(dibenzylamino)-8-oxo-7H-purin-9(8H)-yl)phenyl(methyl)carbamate
CAS No.:1448444-66-3
Molecular Formula:C₃₁H₃₂N₆O₃
Molecular Weight:536.633
Hs Code.:

Synonyms:tert-butyl 3-(6-(dibenzylamino)-8-oxo-7H-purin-9(8H)-yl)phenyl(methyl)carbamate

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Chemical Property of tert-butyl 3-(6-(dibenzylamino)-8-oxo-7H-purin-9(8H)-yl)phenyl(methyl)carbamate

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Technology Process of tert-butyl 3-(6-(dibenzylamino)-8-oxo-7H-purin-9(8H)-yl)phenyl(methyl)carbamate

There total 9 articles about tert-butyl 3-(6-(dibenzylamino)-8-oxo-7H-purin-9(8H)-yl)phenyl(methyl)carbamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 92.0%

: 32315-10-9
bis(trichloromethyl) carbonate

: 1448444-65-2
tert-butyl 3-(5-amino-6-(dibenzylamino)pyrimidin-4-ylamino)phenyl(methyl)carbamate

: 1448444-66-3
tert-butyl 3-(6-(dibenzylamino)-8-oxo-7H-purin-9(8H)-yl)phenyl(methyl)carbamate

Guidance literature:: With triethylamine; In dichloromethane; at 0 ℃; for 2h; Inert atmosphere;

Reference yield:

: 18437-64-4
tert-butyl (3-nitrophenyl)carbamate

: 1448444-66-3
tert-butyl 3-(6-(dibenzylamino)-8-oxo-7H-purin-9(8H)-yl)phenyl(methyl)carbamate

Guidance literature:: Multi-step reaction with 5 steps

1.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 0.5 h / 0 °C

1.2: 2 h / 20 °C

2.1: hydrogen; palladium 10% on activated carbon / tetrahydrofuran; methanol

3.1: triethylamine / 1,4-dioxane / 60 °C

4.1: ammonium chloride; iron / water; tetrahydrofuran; methanol / 5 h / 50 °C / Inert atmosphere

5.1: triethylamine / dichloromethane / 2 h / 0 °C / Inert atmosphere

With palladium 10% on activated carbon; hydrogen; iron; sodium hydride; ammonium chloride; triethylamine; In tetrahydrofuran; 1,4-dioxane; methanol; dichloromethane; water; N,N-dimethyl-formamide; mineral oil;

Reference yield:

: 99-09-2
3-nitro-aniline

: 1448444-66-3
tert-butyl 3-(6-(dibenzylamino)-8-oxo-7H-purin-9(8H)-yl)phenyl(methyl)carbamate

Guidance literature:: Multi-step reaction with 6 steps

1.1: triethylamine; dmap / dichloromethane; ethyl acetate; Petroleum ether / 3 h / 20 °C

2.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 0.5 h / 0 °C

2.2: 2 h / 20 °C

3.1: hydrogen; palladium 10% on activated carbon / tetrahydrofuran; methanol

4.1: triethylamine / 1,4-dioxane / 60 °C

5.1: ammonium chloride; iron / water; tetrahydrofuran; methanol / 5 h / 50 °C / Inert atmosphere

6.1: triethylamine / dichloromethane / 2 h / 0 °C / Inert atmosphere

With dmap; palladium 10% on activated carbon; hydrogen; iron; sodium hydride; ammonium chloride; triethylamine; In tetrahydrofuran; 1,4-dioxane; methanol; dichloromethane; water; ethyl acetate; N,N-dimethyl-formamide; mineral oil; Petroleum ether;