tert-butyl 3-(6-amino-8-oxo-7-(4-phenoxyphenyl)-7H-purin-9(8H)-yl)phenyl(methyl)carbamate

Base Information

Chemical Name:tert-butyl 3-(6-amino-8-oxo-7-(4-phenoxyphenyl)-7H-purin-9(8H)-yl)phenyl(methyl)carbamate
CAS No.:1448444-74-3
Molecular Formula:C₂₉H₂₈N₆O₄
Molecular Weight:524.579
Hs Code.:

Synonyms:tert-butyl 3-(6-amino-8-oxo-7-(4-phenoxyphenyl)-7H-purin-9(8H)-yl)phenyl(methyl)carbamate

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Chemical Property of tert-butyl 3-(6-amino-8-oxo-7-(4-phenoxyphenyl)-7H-purin-9(8H)-yl)phenyl(methyl)carbamate

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Technology Process of tert-butyl 3-(6-amino-8-oxo-7-(4-phenoxyphenyl)-7H-purin-9(8H)-yl)phenyl(methyl)carbamate

There total 9 articles about tert-butyl 3-(6-amino-8-oxo-7-(4-phenoxyphenyl)-7H-purin-9(8H)-yl)phenyl(methyl)carbamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 51.0%

: 1448444-67-4
tert-butyl 3-(6-amino-8-oxo-7H-purin-9(8H)-yl)phenyl(methyl)carbamate

: 51067-38-0
4-phenoxyphenylboronic acid

: 1448444-74-3
tert-butyl 3-(6-amino-8-oxo-7-(4-phenoxyphenyl)-7H-purin-9(8H)-yl)phenyl(methyl)carbamate

Guidance literature:: With pyridine; oxygen; copper diacetate; In N,N-dimethyl-formamide; at 37 ℃; Molecular sieve;

Reference yield:

: 528882-15-7
N-methyl-(3-nitrophenyl)carbamic acid tert-butyl ester

: 1448444-74-3
tert-butyl 3-(6-amino-8-oxo-7-(4-phenoxyphenyl)-7H-purin-9(8H)-yl)phenyl(methyl)carbamate

Guidance literature:: Multi-step reaction with 6 steps

1: hydrogen; palladium 10% on activated carbon / tetrahydrofuran; methanol

2: triethylamine / 1,4-dioxane / 60 °C

3: ammonium chloride; iron / water; tetrahydrofuran; methanol / 5 h / 50 °C / Inert atmosphere

4: triethylamine / dichloromethane / 2 h / 0 °C / Inert atmosphere

5: 10 wt% Pd(OH)2 on carbon; hydrogenchloride; hydrogen / methanol / 60 °C

6: oxygen; copper diacetate; pyridine / N,N-dimethyl-formamide / 37 °C / Molecular sieve

With pyridine; hydrogenchloride; palladium 10% on activated carbon; 10 wt% Pd(OH)2 on carbon; hydrogen; oxygen; copper diacetate; iron; ammonium chloride; triethylamine; In tetrahydrofuran; 1,4-dioxane; methanol; dichloromethane; water; N,N-dimethyl-formamide;

Reference yield:

: 18437-64-4
tert-butyl (3-nitrophenyl)carbamate

: 1448444-74-3
tert-butyl 3-(6-amino-8-oxo-7-(4-phenoxyphenyl)-7H-purin-9(8H)-yl)phenyl(methyl)carbamate

Guidance literature:: Multi-step reaction with 7 steps

1.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 0.5 h / 0 °C

1.2: 2 h / 20 °C

2.1: hydrogen; palladium 10% on activated carbon / tetrahydrofuran; methanol

3.1: triethylamine / 1,4-dioxane / 60 °C

4.1: ammonium chloride; iron / water; tetrahydrofuran; methanol / 5 h / 50 °C / Inert atmosphere

5.1: triethylamine / dichloromethane / 2 h / 0 °C / Inert atmosphere

6.1: 10 wt% Pd(OH)2 on carbon; hydrogenchloride; hydrogen / methanol / 60 °C

7.1: oxygen; copper diacetate; pyridine / N,N-dimethyl-formamide / 37 °C / Molecular sieve

With pyridine; hydrogenchloride; palladium 10% on activated carbon; 10 wt% Pd(OH)2 on carbon; hydrogen; oxygen; copper diacetate; iron; sodium hydride; ammonium chloride; triethylamine; In tetrahydrofuran; 1,4-dioxane; methanol; dichloromethane; water; N,N-dimethyl-formamide; mineral oil;