(R)-5-difluoromethyl-5-(2-fluoro-phenyl)-5,6-dihydro-2H-[1,4]oxazin-3-ylamine sulphate

Base Information

Chemical Name:(R)-5-difluoromethyl-5-(2-fluoro-phenyl)-5,6-dihydro-2H-[1,4]oxazin-3-ylamine sulphate
CAS No.:1356037-26-7
Molecular Formula:C₁₁H₁₁F₃N₂O*H₂O₄S
Molecular Weight:342.296
Hs Code.:

Synonyms:(R)-5-difluoromethyl-5-(2-fluoro-phenyl)-5,6-dihydro-2H-[1,4]oxazin-3-ylamine sulphate

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (R)-5-difluoromethyl-5-(2-fluoro-phenyl)-5,6-dihydro-2H-[1,4]oxazin-3-ylamine sulphate

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Technology Process of (R)-5-difluoromethyl-5-(2-fluoro-phenyl)-5,6-dihydro-2H-[1,4]oxazin-3-ylamine sulphate

There total 2 articles about (R)-5-difluoromethyl-5-(2-fluoro-phenyl)-5,6-dihydro-2H-[1,4]oxazin-3-ylamine sulphate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1356037-24-5
(R)-5-difluoromethyl-5-(2-fluoro-phenyl)-morpholin-3-one

: ammonium hydroxide

: 1356037-26-7
(R)-5-difluoromethyl-5-(2-fluoro-phenyl)-5,6-dihydro-2H-[1,4]oxazin-3-ylamine sulphate

Guidance literature:: With P₂S₅; sulfuric acid; In tetrahydrofuran; methanol; dichloromethane;

Reference yield:

: 1356037-23-4
(R)-2-amino-2-(5-bromo-2-fluoro-phenyl)-3,3-difluoro-propan-1-ol HCl salt

: 1356037-26-7
(R)-5-difluoromethyl-5-(2-fluoro-phenyl)-5,6-dihydro-2H-[1,4]oxazin-3-ylamine sulphate

Guidance literature:: Multi-step reaction with 2 steps

1: potassium carbonate / palladium-carbon / water; tetrahydrofuran; IPAc

2: sulfuric acid; P₂S₅ / dichloromethane; tetrahydrofuran; methanol

With P₂S₅; sulfuric acid; potassium carbonate; palladium-carbon; In tetrahydrofuran; methanol; IPAc; dichloromethane; water;