(R)-5-difluoromethyl-5-(2-fluoro-5-nitro-phenyl)-5,6-dihydro-2H-[1,4]oxazin-3-ylamine

Base Information

Chemical Name:(R)-5-difluoromethyl-5-(2-fluoro-5-nitro-phenyl)-5,6-dihydro-2H-[1,4]oxazin-3-ylamine
CAS No.:1356037-27-8
Molecular Formula:C₁₁H₁₀F₃N₃O₃
Molecular Weight:289.214
Hs Code.:

Synonyms:(R)-5-difluoromethyl-5-(2-fluoro-5-nitro-phenyl)-5,6-dihydro-2H-[1,4]oxazin-3-ylamine

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Chemical Property of (R)-5-difluoromethyl-5-(2-fluoro-5-nitro-phenyl)-5,6-dihydro-2H-[1,4]oxazin-3-ylamine

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Technology Process of (R)-5-difluoromethyl-5-(2-fluoro-5-nitro-phenyl)-5,6-dihydro-2H-[1,4]oxazin-3-ylamine

There total 2 articles about (R)-5-difluoromethyl-5-(2-fluoro-5-nitro-phenyl)-5,6-dihydro-2H-[1,4]oxazin-3-ylamine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1356037-26-7
(R)-5-difluoromethyl-5-(2-fluoro-phenyl)-5,6-dihydro-2H-[1,4]oxazin-3-ylamine sulphate

: ammonium hydroxide

: 1356037-27-8
(R)-5-difluoromethyl-5-(2-fluoro-5-nitro-phenyl)-5,6-dihydro-2H-[1,4]oxazin-3-ylamine

Guidance literature:: With nitric acid; In sulfuric acid;

Reference yield:

: 1356037-23-4
(R)-2-amino-2-(5-bromo-2-fluoro-phenyl)-3,3-difluoro-propan-1-ol HCl salt

: 1356037-27-8
(R)-5-difluoromethyl-5-(2-fluoro-5-nitro-phenyl)-5,6-dihydro-2H-[1,4]oxazin-3-ylamine

Guidance literature:: Multi-step reaction with 3 steps

1: potassium carbonate / palladium-carbon / water; tetrahydrofuran; IPAc

2: sulfuric acid; P₂S₅ / dichloromethane; tetrahydrofuran; methanol

3: nitric acid / sulfuric acid

With P₂S₅; sulfuric acid; nitric acid; potassium carbonate; palladium-carbon; In tetrahydrofuran; methanol; IPAc; dichloromethane; sulfuric acid; water;

Reference yield:

: 1356037-27-8
(R)-5-difluoromethyl-5-(2-fluoro-5-nitro-phenyl)-5,6-dihydro-2H-[1,4]oxazin-3-ylamine

: 5-cyano-3-methyl-pyridine-2-carboxylic acid [3-((R)-5-amino-3-difluoromethyl-3,6-dihydro-2H-[1,4]oxazin-3-yl)-4-fluoro-phenyl]-amide

Guidance literature:: Multi-step reaction with 4 steps

1: DIPEA

2: Pd(OH)2/C / hydrogen; methanol

3: 4-methyl-morpholine / tetrahydrofuran

4: trifluoroacetic acid; ammonia / water; 4-(dicyanomethylene)-2-methyl-6-(p-dimethylaminostyryl)-4H-pyran

With 4-methyl-morpholine; DIPEA; ammonia; trifluoroacetic acid; Pd(OH)2/C; In tetrahydrofuran; methanol; water; hydrogen; 4-(dicyanomethylene)-2-methyl-6-(p-dimethylaminostyryl)-4H-pyran;