4-[but-3-enyl-(toluene-4-sulfonyl)-amino]-N,N-dimethyl-3-oxo-butyramide

Base Information

Chemical Name:4-[but-3-enyl-(toluene-4-sulfonyl)-amino]-N,N-dimethyl-3-oxo-butyramide
CAS No.:871123-32-9
Molecular Formula:C₁₇H₂₄N₂O₄S
Molecular Weight:352.455
Hs Code.:

4-[but-3-enyl-(toluene-4-sulfonyl)-amino]-<i>N</i>,<i>N</i>-dimethyl-3-oxo-butyramide

Synonyms:4-[but-3-enyl-(toluene-4-sulfonyl)-amino]-N,N-dimethyl-3-oxo-butyramide

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Chemical Property of 4-[but-3-enyl-(toluene-4-sulfonyl)-amino]-N,N-dimethyl-3-oxo-butyramide

Chemical Property:

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Technology Process of 4-[but-3-enyl-(toluene-4-sulfonyl)-amino]-N,N-dimethyl-3-oxo-butyramide

There total 3 articles about 4-[but-3-enyl-(toluene-4-sulfonyl)-amino]-N,N-dimethyl-3-oxo-butyramide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 65.0%

: [but-3-enyl-(toluene-4-sulfonyl)-amino]-acetic acid methyl ester

: 127-19-5,116057-81-9
N,N-dimethyl acetamide

: 871123-32-9
4-[but-3-enyl-(toluene-4-sulfonyl)-amino]-N,N-dimethyl-3-oxo-butyramide

Guidance literature:: N,N-dimethyl acetamide; With lithium diisopropyl amide; In tetrahydrofuran; at -78 ℃;

[but-3-enyl-(toluene-4-sulfonyl)-amino]-acetic acid methyl ester; In tetrahydrofuran; at -78 ℃;
DOI:10.1021/ol052529c

Reference yield:

: 2645-02-5
methyl tosylglycinate

: 871123-32-9
4-[but-3-enyl-(toluene-4-sulfonyl)-amino]-N,N-dimethyl-3-oxo-butyramide

Guidance literature:: Multi-step reaction with 2 steps

1.1: 72 percent / K₂CO₃; KI / acetone / Heating

2.1: LDA / tetrahydrofuran / -78 °C

2.2: 65 percent / tetrahydrofuran / -78 °C

With potassium carbonate; potassium iodide; lithium diisopropyl amide; In tetrahydrofuran; acetone;
DOI:10.1021/ol052529c

Reference yield:

: 98-59-9
p-toluenesulfonyl chloride

: 871123-32-9
4-[but-3-enyl-(toluene-4-sulfonyl)-amino]-N,N-dimethyl-3-oxo-butyramide

Guidance literature:: Multi-step reaction with 3 steps

1.1: 98 percent / Et₃N / CH₂Cl₂ / 16 h / 20 °C

2.1: 72 percent / K₂CO₃; KI / acetone / Heating

3.1: LDA / tetrahydrofuran / -78 °C

3.2: 65 percent / tetrahydrofuran / -78 °C

With potassium carbonate; triethylamine; potassium iodide; lithium diisopropyl amide; In tetrahydrofuran; dichloromethane; acetone;
DOI:10.1021/ol052529c