2645-02-5

Basic information

• Product Name: Methyl 2-(4-methylphenylsulfonamido)acetate
• Synonyms: methyl 2-(4-methylphenylsulfonamido)acetate;Methyl 2-[(4-Methylbenzene)sulfonaMido]acetate;Methyl N-[(4-methylphenyl)sulphonyl]glycinate, N-Tosylglycine methyl ester, Methyl [(4-methylphenyl)sulphonamido]acetate;N-(Toluene-4-sulphonyl)glycine methyl ester;methyl 2-[(4-methylphenyl)sulfonylamino]acetate;methyltosylglycinate;T0514-7020;TsNHCH2COOCH3
• CAS NO: 2645-02-5
• Molecular Formula: C₁₀H₁₃NO₄S
• Molecular Weight: 243.28
• Mol File: 2645-02-5.mol
• Article Data: 29

Chemical Properties

• Melting Point: 89-91°C
• Boiling Point: 372.5 °C at 760 mmHg
• Flash Point: 179.1 °C
• Appearance: /
• Density: 1.261
• Storage Temp.: Sealed in dry,Room Temperature
• Solubility: Chloroform (Slightly), Methanol (Slightly)
• PKA: 9.09±0.50(Predicted)
• CAS DataBase Reference: Methyl 2-(4-methylphenylsulfonamido)acetate(CAS DataBase Reference)
• NIST Chemistry Reference: Methyl 2-(4-methylphenylsulfonamido)acetate(2645-02-5)
• EPA Substance Registry System: Methyl 2-(4-methylphenylsulfonamido)acetate(2645-02-5)

Safety Data

• Hazardous Substances Data: 2645-02-5(Hazardous Substances Data)

Usage

General Description

Methyl 2-(4-methylphenylsulfonamido)acetate is a chemical compound with a molecular formula C11H15NO4S. It is a sulfonamide derivative that contains a sulfonamido group attached to a methyl acetate group. Methyl 2-(4-methylphenylsulfonamido)acetate is commonly used in the synthesis of pharmaceuticals and agrochemicals due to its potential as a building block for biologically active compounds. It is also used as a reagent in organic chemistry reactions, particularly in the formation of amide and ester compounds. Methyl 2-(4-methylphenylsulfonamido)acetate is a white crystalline solid that is soluble in organic solvents and has a relatively high melting point. Its properties and reactivity make it a valuable tool in the development and production of various chemical products.

Upstream product

• 67-56-1 methanol 
• 1080-44-0 N-Tosylglycine 
• 104-15-4 toluene-4-sulfonic acid 
• 98-59-9 p-toluenesulfonyl chloride 
• 616-34-2 methoxycarbonylmethylamine 
• 941-55-9 4-toluenesulfonyl azide 
• 20992-37-4 ethyl (2E)-cyano({[(4-methylphenyl)sulfonyl]oxy}imino)acetate 
• 21978-63-2 1H-benzo[d][1,2,3]triazol-1-yl 4-methanebenzenesulfonate 
• 61985-23-7 methyl 1-imidazolecarboxylate 
• 1738-68-7 Gly-OBz 
• 18522-92-4 sodium p-toluenesulfonamide 
• 36850-80-3 [(1-methoxyvinyl)oxy]trimethylsilane 
• 79-20-9 acetic acid methyl ester 
• 63366-76-7 (toluene-4-sulfonylamino)acetic acid benzyl ester 

Downstream Products

• 100371-35-5 p-toluenesulfonylglycine isopropyl ester 
• 59724-90-2 (toluene-4-sulfonylimino)-di-acetic acid dimethyl ester 
• 566883-81-6 N-(p-methylbenzyl)-N-(p-toluenesulfonyl)glycine methyl ester 
• 922190-43-0 methyl 2-(4-methyl-N-(3-phenylprop-2-ynyl)phenylsulfonamido)acetate 
• 99069-27-9 oxalomonohydroximic acid-2-methyl ester-1-(toluene-4-sulfonylamide) 
• 934621-66-6 ethyl 2-({(2-methoxy-2-oxoethyl)[(4-methylphenyl)sulfonyl]amino}methyl)-1-(phenylsulfonyl)-1H-pyrrole-3-carboxylate 
• 915230-27-2 3-hydroxy-4-isopropyl-1-(toluene-4-sulfonyl)-pyrrolidine-2-carboxylic acid methyl ester 
• 945740-52-3 2-{[methoxycarbonylmethyl-(toluene-4-sulfonyl)-amino]-methyl}-6-phenoxy-benzoic acid methyl ester 
• 945740-62-5 3-iodo-2-{[methoxycarbonylmethyl-(toluene-4-sulfonyl)-amino]-methyl}-benzoic acid methyl ester 
• 1132762-32-3 C₁₅H₁₇NO₄S 
• 886147-31-5 benzaldehyde N-(4-toluenesulfonyl)-glycinyl hydrazone 
• 354146-82-0 2-furaldehyde N-(4-toluenesulfonyl)-glycinyl hydrazone 
• 444050-60-6 4-methylbenzaldehyde N-(4-toluenesulfonyl)-glycinyl hydrazone 
• 331426-83-6 4-methoxybenzaldehyde N-(4-toluenesulfonyl)-glycinyl hydrazone 

Relevant articles and documents

A practical method for N-cyanation of secondary amines and sulfonamides

Cyanamides are an important class of molecules. This work describes a facile synthesis of disubstituted cyanamides. Here, readily accessible 1-cyano-1, 2-benziodoxol-3-(1H)-one (CBX) was applied as a stable electrophilic cyanation reagent. Diverse secondary amines were effectively cyanated. Moreover, secondary sulfonamides proved to be suitable substrates and were readily converted to N-alkyl(aryl)-N-arylsulfonyl-cyanamides, as the significant building blocks of the organic transformation.

Nitroxyl Catalysts for Six-Membered Ring Bromolactonization and Intermolecular Bromoesterification of Alkenes with Carboxylic Acids

We developed a nitroxyl-catalyzed bromoesterification of alkenes with bromo reagents, which includes a six-membered ring bromolactonization of alkenyl carboxylic acids catalyzed by AZADO as the nitroxyl radical catalyst, and an intermolecular bromoesterification of alkenes with carboxylic acids using NMO as the N-oxide catalyst. We also accomplished a remote diastereoselective bromohydroxylation via an AZADO-catalyzed six-membered ring bromolactonization and a subsequent ring cleavage reaction with alkylamines to furnish ?-bromo-δ-hydroxy amides with high diastereoselectivity.

ANTIVIRAL 1,3-DI-OXO-INDENE COMPOUNDS

The invention provides compounds of Formula (I): as described herein, along with pharmaceutically acceptable salts, pharmaceutical compositions containing such compounds, and methods to use these compounds, salts and compositions for treating viral infections.