2-(4-Chloro-3-methoxyphenyl)ethan-1-amine

Base Information

Chemical Name:2-(4-Chloro-3-methoxyphenyl)ethan-1-amine
CAS No.:96495-22-6
Molecular Formula:C₉H₁₂ClNO
Molecular Weight:185.653
Hs Code.:
European Community (EC) Number:819-198-2
ChEMBL ID:CHEMBL4533435

Synonyms:2-(4-Chloro-3-methoxyphenyl)ethan-1-amine;96495-22-6;2-(4-chloro-3-methoxyphenyl)ethanamine;Benzeneethanamine, 4-chloro-3-methoxy-;SCHEMBL793618;CHEMBL4533435;WXOYNGLGBUBNFN-UHFFFAOYSA-N;AKOS017530045;EN300-225009;A902478;A1-00609

Suppliers and Price of 2-(4-Chloro-3-methoxyphenyl)ethan-1-amine

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 4 raw suppliers

Chemical Property of 2-(4-Chloro-3-methoxyphenyl)ethan-1-amine

Chemical Property:

XLogP3:1.4
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:2
Rotatable Bond Count:3
Exact Mass:185.0607417
Heavy Atom Count:12
Complexity:132

Purity/Quality:: 97% ^*data from raw suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Canonical SMILES:COC1=C(C=CC(=C1)CCN)Cl

Technology Process of 2-(4-Chloro-3-methoxyphenyl)ethan-1-amine

There total 7 articles about 2-(4-Chloro-3-methoxyphenyl)ethan-1-amine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

: 144181-28-2
1-chloro-2-methoxy-4-(2-nitrovinyl)benzene

: 96495-22-6
2-(4-chloro-3-methoxyphenyl)ethylamine

Guidance literature:: With lithium aluminium tetrahydride; In tetrahydrofuran;

Reference yield:

: 13726-16-4
4-chloro-3-methoxybenzaldehyde

: 96495-22-6
2-(4-chloro-3-methoxyphenyl)ethylamine

Guidance literature:: Multi-step reaction with 2 steps

1: 89 percent / CH₃NH₂*HCl, Na₂CO₃ / ethanol / 72 h / Ambient temperature

2: 55 percent / LiAlH₄ / tetrahydrofuran / 12 h / Ambient temperature

With lithium aluminium tetrahydride; methylamine hydrochloride; sodium carbonate; In tetrahydrofuran; ethanol;
DOI:10.1021/jm00101a018

Reference yield:

: 615-74-7
2-chloro-5-methylphenol

: 96495-22-6
2-(4-chloro-3-methoxyphenyl)ethylamine

Guidance literature:: Multi-step reaction with 6 steps

1: 80 percent / K₂CO₃ / acetone

2: 92 percent / KMnO₄ / pyridine; H₂O / 1.) 50 deg C, 24 h, 2.) RT, 13 h

3: 82 percent / LiAlH₄ / diethyl ether; dioxane

4: 93 percent / pyridinium chlorochromate / CH₂Cl₂

5: 89 percent / CH₃NH₂*HCl, Na₂CO₃ / ethanol / 72 h / Ambient temperature

6: 55 percent / LiAlH₄ / tetrahydrofuran / 12 h / Ambient temperature

With potassium permanganate; lithium aluminium tetrahydride; methylamine hydrochloride; sodium carbonate; potassium carbonate; pyridinium chlorochromate; In tetrahydrofuran; 1,4-dioxane; pyridine; diethyl ether; ethanol; dichloromethane; water; acetone;
DOI:10.1021/jm00101a018