(E)-ethyl 2-(7-(benzyloxy)-2,3-dihydro-1H-pyrrolo[1,2-a]indol-1-ylidene)acetate

Base Information

Chemical Name:(E)-ethyl 2-(7-(benzyloxy)-2,3-dihydro-1H-pyrrolo[1,2-a]indol-1-ylidene)acetate
CAS No.:1333379-87-5
Molecular Formula:C₂₂H₂₁NO₃
Molecular Weight:347.414
Hs Code.:

Synonyms:(E)-ethyl 2-(7-(benzyloxy)-2,3-dihydro-1H-pyrrolo[1,2-a]indol-1-ylidene)acetate

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Chemical Property of (E)-ethyl 2-(7-(benzyloxy)-2,3-dihydro-1H-pyrrolo[1,2-a]indol-1-ylidene)acetate

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Technology Process of (E)-ethyl 2-(7-(benzyloxy)-2,3-dihydro-1H-pyrrolo[1,2-a]indol-1-ylidene)acetate

There total 5 articles about (E)-ethyl 2-(7-(benzyloxy)-2,3-dihydro-1H-pyrrolo[1,2-a]indol-1-ylidene)acetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 58.0%

: 867-13-0
diethoxyphosphoryl-acetic acid ethyl ester

: 3418-69-7
7-(benzyloxy)-2,3-dihydro-1H-pyrrolo[1,2-a]indol-1-one

: 1333379-87-5
(E)-ethyl 2-(7-(benzyloxy)-2,3-dihydro-1H-pyrrolo[1,2-a]indol-1-ylidene)acetate

Guidance literature:: With potassium tert-butylate; In tetrahydrofuran; at 20 - 29 ℃; for 18.1667h; Inert atmosphere;

Reference yield:

: 37033-95-7
5-benzyloxy-1H-indole-2-carboxylic acid ethyl ester

: 1333379-87-5
(E)-ethyl 2-(7-(benzyloxy)-2,3-dihydro-1H-pyrrolo[1,2-a]indol-1-ylidene)acetate

Guidance literature:: Multi-step reaction with 3 steps

1: potassium tert-butylate / tetrahydrofuran / 19.5 h / 20 - 34 °C / Inert atmosphere; Reflux

2: water; acetic acid / 40 h / Reflux

3: potassium tert-butylate / tetrahydrofuran / 18.17 h / 20 - 29 °C / Inert atmosphere

With potassium tert-butylate; water; acetic acid; In tetrahydrofuran;

Reference yield:

: 1333379-86-4
potassium 7-(benzyloxy)-2-(ethoxycarbonyl)-3H-pyrrolo[1,2-a]indol-1-olate

: 1333379-87-5
(E)-ethyl 2-(7-(benzyloxy)-2,3-dihydro-1H-pyrrolo[1,2-a]indol-1-ylidene)acetate

Guidance literature:: Multi-step reaction with 2 steps

1: water; acetic acid / 40 h / Reflux

2: potassium tert-butylate / tetrahydrofuran / 18.17 h / 20 - 29 °C / Inert atmosphere

With potassium tert-butylate; water; acetic acid; In tetrahydrofuran;