N-acetyl-N'-[3-(2-oxotetrahydropyrimidin-1(2H)-yl)propyl]-O-phosphono-L-tyrosinamide

Base Information

Chemical Name:N-acetyl-N'-[3-(2-oxotetrahydropyrimidin-1(2H)-yl)propyl]-O-phosphono-L-tyrosinamide
CAS No.:1268157-38-5
Molecular Formula:C₁₈H₂₇N₄O₇P
Molecular Weight:442.409
Hs Code.:

Synonyms:N-acetyl-N'-[3-(2-oxotetrahydropyrimidin-1(2H)-yl)propyl]-O-phosphono-L-tyrosinamide

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of N-acetyl-N'-[3-(2-oxotetrahydropyrimidin-1(2H)-yl)propyl]-O-phosphono-L-tyrosinamide

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Technology Process of N-acetyl-N'-[3-(2-oxotetrahydropyrimidin-1(2H)-yl)propyl]-O-phosphono-L-tyrosinamide

There total 5 articles about N-acetyl-N'-[3-(2-oxotetrahydropyrimidin-1(2H)-yl)propyl]-O-phosphono-L-tyrosinamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 47.0%

: 1268157-53-4
N-acetyl-O-[bis(benzyloxy)phosphoryl]-N'-[3-(2-oxotetrahydropyrimidin-1(2H)-yl)propyl]-L-tyrosinamide

: 1268157-38-5
N-acetyl-N'-[3-(2-oxotetrahydropyrimidin-1(2H)-yl)propyl]-O-phosphono-L-tyrosinamide

Guidance literature:: With palladium 10% on activated carbon; hydrogen; In ethanol; under 2327.23 Torr;
DOI:10.1021/jm101478n

Reference yield:

: 537-55-3
N-acetyl-L-tyrosine

: 1268157-38-5
N-acetyl-N'-[3-(2-oxotetrahydropyrimidin-1(2H)-yl)propyl]-O-phosphono-L-tyrosinamide

Guidance literature:: Multi-step reaction with 6 steps

1.1: 4-methyl-morpholine / acetonitrile / 0.17 h / 20 °C

2.1: 1H-tetrazole / acetonitrile / 3 h / 20 °C

3.1: tert.-butylhydroperoxide / water; acetonitrile / 0.17 h / 20 °C

4.1: water; acetic acid / tetrahydrofuran / 3 h / 20 °C

5.1: benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / dichloromethane / 0.5 h / 20 °C / Inert atmosphere

5.2: 2.17 h / 0 - 20 °C / Inert atmosphere

6.1: palladium 10% on activated carbon; hydrogen / ethanol / 2327.23 Torr

With 4-methyl-morpholine; 1H-tetrazole; tert.-butylhydroperoxide; palladium 10% on activated carbon; water; hydrogen; benzotriazol-1-ol; acetic acid; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In tetrahydrofuran; ethanol; dichloromethane; water; acetonitrile;
DOI:10.1021/jm101478n

Reference yield:

: C₁₇H₂₇NO₄Si

: 1268157-38-5
N-acetyl-N'-[3-(2-oxotetrahydropyrimidin-1(2H)-yl)propyl]-O-phosphono-L-tyrosinamide

Guidance literature:: Multi-step reaction with 5 steps

1.1: 1H-tetrazole / acetonitrile / 3 h / 20 °C

2.1: tert.-butylhydroperoxide / water; acetonitrile / 0.17 h / 20 °C

3.1: water; acetic acid / tetrahydrofuran / 3 h / 20 °C

4.1: benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / dichloromethane / 0.5 h / 20 °C / Inert atmosphere

4.2: 2.17 h / 0 - 20 °C / Inert atmosphere

5.1: palladium 10% on activated carbon; hydrogen / ethanol / 2327.23 Torr

With 1H-tetrazole; tert.-butylhydroperoxide; palladium 10% on activated carbon; water; hydrogen; benzotriazol-1-ol; acetic acid; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In tetrahydrofuran; ethanol; dichloromethane; water; acetonitrile;
DOI:10.1021/jm101478n