8-(benzyloxy)-5-{1-{[tert-butyl(dimethyl)silyl]oxy}-2-[(6-{2-[(2,6-dichlorobenzyl)(methyl)amino]ethoxy}hexyl)amino]ethyl}quinolin-2(1H)-one

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Chemical Name:8-(benzyloxy)-5-{1-{[tert-butyl(dimethyl)silyl]oxy}-2-[(6-{2-[(2,6-dichlorobenzyl)(methyl)amino]ethoxy}hexyl)amino]ethyl}quinolin-2(1H)-one
CAS No.:956235-87-3
Molecular Formula:C₄₀H₅₅Cl₂N₃O₄Si
Molecular Weight:740.886
Hs Code.:

Synonyms:8-(benzyloxy)-5-{1-{[tert-butyl(dimethyl)silyl]oxy}-2-[(6-{2-[(2,6-dichlorobenzyl)(methyl)amino]ethoxy}hexyl)amino]ethyl}quinolin-2(1H)-one

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Chemical Property of 8-(benzyloxy)-5-{1-{[tert-butyl(dimethyl)silyl]oxy}-2-[(6-{2-[(2,6-dichlorobenzyl)(methyl)amino]ethoxy}hexyl)amino]ethyl}quinolin-2(1H)-one

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Technology Process of 8-(benzyloxy)-5-{1-{[tert-butyl(dimethyl)silyl]oxy}-2-[(6-{2-[(2,6-dichlorobenzyl)(methyl)amino]ethoxy}hexyl)amino]ethyl}quinolin-2(1H)-one

There total 11 articles about 8-(benzyloxy)-5-{1-{[tert-butyl(dimethyl)silyl]oxy}-2-[(6-{2-[(2,6-dichlorobenzyl)(methyl)amino]ethoxy}hexyl)amino]ethyl}quinolin-2(1H)-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 915133-14-1
(R,S)-8-(benzyloxy)-5-(2-bromo-1-{[tert-butyl(dimethyl)silyl]oxy}ethyl)quinolin-2(1H)-one

: 956234-45-0
6-{2-[(2,6-dichlorobenzyl)(methyl)amino]ethoxy}hexan-1-amine

: 956235-87-3
8-(benzyloxy)-5-{1-{[tert-butyl(dimethyl)silyl]oxy}-2-[(6-{2-[(2,6-dichlorobenzyl)(methyl)amino]ethoxy}hexyl)amino]ethyl}quinolin-2(1H)-one

Guidance literature:: With sodium hydrogencarbonate; sodium iodide; In dimethyl sulfoxide; at 140 ℃; for 2h;

Reference yield:

: 629-03-8
1 ,6-dibromohexane

: 956235-87-3
8-(benzyloxy)-5-{1-{[tert-butyl(dimethyl)silyl]oxy}-2-[(6-{2-[(2,6-dichlorobenzyl)(methyl)amino]ethoxy}hexyl)amino]ethyl}quinolin-2(1H)-one

Guidance literature:: Multi-step reaction with 7 steps

1: sodium hydroxide / tetrabutylammomium bromide / water / 5 h / 20 °C

2: cetyltributylphosphonium bromide / N,N-dimethyl-formamide / 3 h / 75 °C

3: hydrogen / palladium 10% on activated carbon / methanol / 2 h / 20 °C / 2070.21 Torr

4: triethylamine / dichloromethane / 20 °C

5: N-ethyl-N,N-diisopropylamine / 16 h / 45 °C

6: hydrazine / ethanol / 72 h / 20 °C

7: sodium hydrogencarbonate; sodium iodide / dimethyl sulfoxide / 2 h / 140 °C

With sodium hydroxide; hydrogen; sodium hydrogencarbonate; triethylamine; N-ethyl-N,N-diisopropylamine; sodium iodide; hydrazine; palladium 10% on activated carbon; tetrabutylammomium bromide; cetyltributylphosphonium bromide; In methanol; ethanol; dichloromethane; water; dimethyl sulfoxide; N,N-dimethyl-formamide;

Reference yield:

: 503068-31-3
[({2-[(6-bromohexyl)oxy]ethyl}oxy)methyl]benzene

: 956235-87-3
8-(benzyloxy)-5-{1-{[tert-butyl(dimethyl)silyl]oxy}-2-[(6-{2-[(2,6-dichlorobenzyl)(methyl)amino]ethoxy}hexyl)amino]ethyl}quinolin-2(1H)-one

Guidance literature:: Multi-step reaction with 6 steps

1: cetyltributylphosphonium bromide / N,N-dimethyl-formamide / 3 h / 75 °C

2: hydrogen / palladium 10% on activated carbon / methanol / 2 h / 20 °C / 2070.21 Torr

3: triethylamine / dichloromethane / 20 °C

4: N-ethyl-N,N-diisopropylamine / 16 h / 45 °C

5: hydrazine / ethanol / 72 h / 20 °C

6: sodium hydrogencarbonate; sodium iodide / dimethyl sulfoxide / 2 h / 140 °C

With hydrogen; sodium hydrogencarbonate; triethylamine; N-ethyl-N,N-diisopropylamine; sodium iodide; hydrazine; palladium 10% on activated carbon; cetyltributylphosphonium bromide; In methanol; ethanol; dichloromethane; dimethyl sulfoxide; N,N-dimethyl-formamide;