5S-[4S-(1-hydroxy-1-methylethyl)-5-oxotetrahydrofuran-2S-yl]-3S-isopropyl-2R-phenylpyrrolidin-1-carboxylic acid tert-butyl ester

Base Information

Chemical Name:5S-[4S-(1-hydroxy-1-methylethyl)-5-oxotetrahydrofuran-2S-yl]-3S-isopropyl-2R-phenylpyrrolidin-1-carboxylic acid tert-butyl ester
CAS No.:441794-74-7
Molecular Formula:C₂₅H₃₇NO₅
Molecular Weight:431.572
Hs Code.:

Synonyms:5S-[4S-(1-hydroxy-1-methylethyl)-5-oxotetrahydrofuran-2S-yl]-3S-isopropyl-2R-phenylpyrrolidin-1-carboxylic acid tert-butyl ester

Suppliers and Price of 5S-[4S-(1-hydroxy-1-methylethyl)-5-oxotetrahydrofuran-2S-yl]-3S-isopropyl-2R-phenylpyrrolidin-1-carboxylic acid tert-butyl ester

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of 5S-[4S-(1-hydroxy-1-methylethyl)-5-oxotetrahydrofuran-2S-yl]-3S-isopropyl-2R-phenylpyrrolidin-1-carboxylic acid tert-butyl ester

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of 5S-[4S-(1-hydroxy-1-methylethyl)-5-oxotetrahydrofuran-2S-yl]-3S-isopropyl-2R-phenylpyrrolidin-1-carboxylic acid tert-butyl ester

There total 7 articles about 5S-[4S-(1-hydroxy-1-methylethyl)-5-oxotetrahydrofuran-2S-yl]-3S-isopropyl-2R-phenylpyrrolidin-1-carboxylic acid tert-butyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.0%

: 67-64-1
acetone

: 441794-73-6
3S-isopropyl-5S-(5-oxotetrahydrofuran-2S-yl)-2R-phenylpyrrolidin-1-carboxylic acid tert-butyl ester

: 441794-74-7
5S-[4S-(1-hydroxy-1-methylethyl)-5-oxotetrahydrofuran-2S-yl]-3S-isopropyl-2R-phenylpyrrolidin-1-carboxylic acid tert-butyl ester

Guidance literature:: With lithium hexamethyldisilazane; In tetrahydrofuran; at -78 ℃; for 1h;
DOI:10.1021/jo011184i

Reference yield:

: (2S,3R,8aS)-2-Isopropyl-5,8-dioxo-3-phenyl-octahydro-indolizine-7-carboxylic acid benzyl ester

: 441794-74-7
5S-[4S-(1-hydroxy-1-methylethyl)-5-oxotetrahydrofuran-2S-yl]-3S-isopropyl-2R-phenylpyrrolidin-1-carboxylic acid tert-butyl ester

Guidance literature:: Multi-step reaction with 5 steps

1: 570 mg / H₂ / Pd/C / methanol

2: 66 percent / L-Selectride / tetrahydrofuran / 1 h / -78 °C

3: HCl conc. / methanol / 72 h / Heating

4: 245 mg / DMAP; Et₃N / acetonitrile

5: 85 percent / LiHMDS / tetrahydrofuran / 1 h / -78 °C

With hydrogenchloride; dmap; hydrogen; L-Selectride; triethylamine; lithium hexamethyldisilazane; palladium on activated charcoal; In tetrahydrofuran; methanol; acetonitrile;
DOI:10.1021/jo011184i

Reference yield:

: 441794-70-3
1-(3-benzyloxycarbonylpropionyl)-4S-isopropyl-5R-phenylpyrrolidine-2S-carboxylic acid methyl ester

: 441794-74-7
5S-[4S-(1-hydroxy-1-methylethyl)-5-oxotetrahydrofuran-2S-yl]-3S-isopropyl-2R-phenylpyrrolidin-1-carboxylic acid tert-butyl ester

Guidance literature:: Multi-step reaction with 6 steps

1: sodium tert-pentoxide / tetrahydrofuran / -20 °C

2: 570 mg / H₂ / Pd/C / methanol

3: 66 percent / L-Selectride / tetrahydrofuran / 1 h / -78 °C

4: HCl conc. / methanol / 72 h / Heating

5: 245 mg / DMAP; Et₃N / acetonitrile

6: 85 percent / LiHMDS / tetrahydrofuran / 1 h / -78 °C

With hydrogenchloride; dmap; hydrogen; sodium tert-pentoxide; L-Selectride; triethylamine; lithium hexamethyldisilazane; palladium on activated charcoal; In tetrahydrofuran; methanol; acetonitrile; 1: Dieckmann cyclization;
DOI:10.1021/jo011184i