Technology Process of N1-((4-((2-(1H-pyrazol-1-yl)benzyl)amino)-8-isopropylpyrazolo[1,5-a][1,3,5]triazin-2-yl)methyl)ethane-1,2-diamine
There total 13 articles about N1-((4-((2-(1H-pyrazol-1-yl)benzyl)amino)-8-isopropylpyrazolo[1,5-a][1,3,5]triazin-2-yl)methyl)ethane-1,2-diamine which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
With
trifluoroacetic acid;
In
dichloromethane;
at 0 ℃;
- Guidance literature:
-
Multi-step reaction with 13 steps
1: dichloromethane / 2 h
2: acetonitrile / 2 h / Reflux
3: sodium hydroxide / water; ethanol / Cooling with ice
4: N,N-diethylaniline; trichlorophosphate / 3 h / 90 °C
5: N-ethyl-N,N-diisopropylamine / acetonitrile / 50 °C
6: 3-chloro-benzenecarboperoxoic acid / dichloromethane / 4 h / 30 °C
7: 1-methyl-pyrrolidin-2-one / 4 h / 80 °C
8: hydrogenchloride / 60 °C
9: hydrogenchloride; water / ethanol / 20 °C
10: lithium aluminium tetrahydride / tetrahydrofuran / 1 h / 0 °C
11: Dess-Martin periodane / dichloromethane / 3 h / 0 - 20 °C
12: C6H15N*C2H4O / methanol / 1 h / 80 °C
13: trifluoroacetic acid / dichloromethane / 0 °C
With
hydrogenchloride; lithium aluminium tetrahydride; C6H15N*C2H4O; water; Dess-Martin periodane; N-ethyl-N,N-diisopropylamine; 3-chloro-benzenecarboperoxoic acid; trifluoroacetic acid; N,N-diethylaniline; sodium hydroxide; trichlorophosphate;
In
tetrahydrofuran; 1-methyl-pyrrolidin-2-one; methanol; ethanol; dichloromethane; water; acetonitrile;
- Guidance literature:
-
Multi-step reaction with 8 steps
1: 3-chloro-benzenecarboperoxoic acid / dichloromethane / 4 h / 30 °C
2: 1-methyl-pyrrolidin-2-one / 4 h / 80 °C
3: hydrogenchloride / 60 °C
4: hydrogenchloride; water / ethanol / 20 °C
5: lithium aluminium tetrahydride / tetrahydrofuran / 1 h / 0 °C
6: Dess-Martin periodane / dichloromethane / 3 h / 0 - 20 °C
7: C6H15N*C2H4O / methanol / 1 h / 80 °C
8: trifluoroacetic acid / dichloromethane / 0 °C
With
hydrogenchloride; lithium aluminium tetrahydride; C6H15N*C2H4O; water; Dess-Martin periodane; 3-chloro-benzenecarboperoxoic acid; trifluoroacetic acid;
In
tetrahydrofuran; 1-methyl-pyrrolidin-2-one; methanol; ethanol; dichloromethane;
