Technology Process of (4-(benzyloxy)-1-cyanocyclohexyl)methyl 4-methylbenzenesulfonate
There total 4 articles about (4-(benzyloxy)-1-cyanocyclohexyl)methyl 4-methylbenzenesulfonate which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
Multi-step reaction with 5 steps
1.1: triethylamine; chloroformic acid ethyl ester / dichloromethane / 0.17 h / -20 - -10 °C / Inert atmosphere
1.2: -20 - -15 °C
2.1: trifluoroacetic anhydride / 0.5 h / 20 °C
3.1: lithium diisopropyl amide / tetrahydrofuran; toluene; n-heptane / 2 h / -78 °C / Inert atmosphere
3.2: -78 - 20 °C / Inert atmosphere
4.1: water; sodium tetrahydroborate / tetrahydrofuran / 18 h / 20 °C
5.1: dmap; triethylamine / dichloromethane / 20 °C
With
dmap; sodium tetrahydroborate; water; chloroformic acid ethyl ester; triethylamine; trifluoroacetic anhydride; lithium diisopropyl amide;
In
tetrahydrofuran; n-heptane; dichloromethane; toluene;
- Guidance literature:
-
Multi-step reaction with 3 steps
1.1: lithium diisopropyl amide / tetrahydrofuran; toluene; n-heptane / 2 h / -78 °C / Inert atmosphere
1.2: -78 - 20 °C / Inert atmosphere
2.1: water; sodium tetrahydroborate / tetrahydrofuran / 18 h / 20 °C
3.1: dmap; triethylamine / dichloromethane / 20 °C
With
dmap; sodium tetrahydroborate; water; triethylamine; lithium diisopropyl amide;
In
tetrahydrofuran; n-heptane; dichloromethane; toluene;
- Guidance literature:
-
Multi-step reaction with 4 steps
1.1: trifluoroacetic anhydride / 0.5 h / 20 °C
2.1: lithium diisopropyl amide / tetrahydrofuran; toluene; n-heptane / 2 h / -78 °C / Inert atmosphere
2.2: -78 - 20 °C / Inert atmosphere
3.1: water; sodium tetrahydroborate / tetrahydrofuran / 18 h / 20 °C
4.1: dmap; triethylamine / dichloromethane / 20 °C
With
dmap; sodium tetrahydroborate; water; triethylamine; trifluoroacetic anhydride; lithium diisopropyl amide;
In
tetrahydrofuran; n-heptane; dichloromethane; toluene;
