ethyl 4-(benzyloxy)-1-cyanocyclohexanecarboxylate

Base Information

Chemical Name:ethyl 4-(benzyloxy)-1-cyanocyclohexanecarboxylate
CAS No.:1421270-74-7
Molecular Formula:C₁₇H₂₁NO₃
Molecular Weight:287.359
Hs Code.:

Synonyms:ethyl 4-(benzyloxy)-1-cyanocyclohexanecarboxylate

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Chemical Property of ethyl 4-(benzyloxy)-1-cyanocyclohexanecarboxylate

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Technology Process of ethyl 4-(benzyloxy)-1-cyanocyclohexanecarboxylate

There total 3 articles about ethyl 4-(benzyloxy)-1-cyanocyclohexanecarboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 33.0%

: 95233-32-2
4-(benzyloxy)cyclohexanecarbonitrile

: 541-41-3
chloroformic acid ethyl ester

: 1421270-74-7
ethyl 4-(benzyloxy)-1-cyanocyclohexanecarboxylate

Guidance literature:: 4-(benzyloxy)cyclohexanecarbonitrile; With lithium diisopropyl amide; In tetrahydrofuran; n-heptane; toluene; at -78 ℃; for 2h; Inert atmosphere;

chloroformic acid ethyl ester; In tetrahydrofuran; n-heptane; toluene; at -78 - 20 ℃; Inert atmosphere;

Reference yield:

: 4-(benzyloxy)cyclohexanecarboxamide

: 1421270-74-7
ethyl 4-(benzyloxy)-1-cyanocyclohexanecarboxylate

Guidance literature:: Multi-step reaction with 2 steps

1.1: trifluoroacetic anhydride / 0.5 h / 20 °C

2.1: lithium diisopropyl amide / tetrahydrofuran; toluene; n-heptane / 2 h / -78 °C / Inert atmosphere

2.2: -78 - 20 °C / Inert atmosphere

With trifluoroacetic anhydride; lithium diisopropyl amide; In tetrahydrofuran; n-heptane; toluene;

Reference yield:

: 66500-40-1
4-(benzyloxy)cyclohexanecarboxylic acid

: 1421270-74-7
ethyl 4-(benzyloxy)-1-cyanocyclohexanecarboxylate

Guidance literature:: Multi-step reaction with 3 steps

1.1: triethylamine; chloroformic acid ethyl ester / dichloromethane / 0.17 h / -20 - -10 °C / Inert atmosphere

1.2: -20 - -15 °C

2.1: trifluoroacetic anhydride / 0.5 h / 20 °C

3.1: lithium diisopropyl amide / tetrahydrofuran; toluene; n-heptane / 2 h / -78 °C / Inert atmosphere

3.2: -78 - 20 °C / Inert atmosphere

With chloroformic acid ethyl ester; triethylamine; trifluoroacetic anhydride; lithium diisopropyl amide; In tetrahydrofuran; n-heptane; dichloromethane; toluene;