(5-[4-(ethylsulfonyl)phenoxy]-2-(pyridin-2-yl)-1-{[2-(trimethylsilyl)ethoxy]methyl}-1H-benzimidazol-6-yl)acetic acid

Base Information

Chemical Name:(5-[4-(ethylsulfonyl)phenoxy]-2-(pyridin-2-yl)-1-{[2-(trimethylsilyl)ethoxy]methyl}-1H-benzimidazol-6-yl)acetic acid
CAS No.:886982-98-5
Molecular Formula:C₂₈H₃₃N₃O₆SSi
Molecular Weight:567.738
Hs Code.:

Synonyms:(5-[4-(ethylsulfonyl)phenoxy]-2-(pyridin-2-yl)-1-{[2-(trimethylsilyl)ethoxy]methyl}-1H-benzimidazol-6-yl)acetic acid

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Chemical Property of (5-[4-(ethylsulfonyl)phenoxy]-2-(pyridin-2-yl)-1-{[2-(trimethylsilyl)ethoxy]methyl}-1H-benzimidazol-6-yl)acetic acid

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Technology Process of (5-[4-(ethylsulfonyl)phenoxy]-2-(pyridin-2-yl)-1-{[2-(trimethylsilyl)ethoxy]methyl}-1H-benzimidazol-6-yl)acetic acid

There total 3 articles about (5-[4-(ethylsulfonyl)phenoxy]-2-(pyridin-2-yl)-1-{[2-(trimethylsilyl)ethoxy]methyl}-1H-benzimidazol-6-yl)acetic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 886979-22-2
(5-[4-(ethylsulfonyl)phenoxy]-2-(pyridin-2-yl)-1-{[2-(trimethylsilyl)ethoxy]methyl}-1H-benzimidazol-6-yl)acetonitrile

: 886982-98-5
(5-[4-(ethylsulfonyl)phenoxy]-2-(pyridin-2-yl)-1-{[2-(trimethylsilyl)ethoxy]methyl}-1H-benzimidazol-6-yl)acetic acid

Guidance literature:: (5-[4-(ethylsulfonyl)phenoxy]-2-(pyridin-2-yl)-1-{[2-(trimethylsilyl)ethoxy]methyl}-1H-benzimidazol-6-yl)acetonitrile; With methanol; sodium hydroxide; water; In tetrahydrofuran; at 100 ℃;

With water; citric acid; In tetrahydrofuran;

Reference yield:

: 886979-22-2
(5-[4-(ethylsulfonyl)phenoxy]-2-(pyridin-2-yl)-1-{[2-(trimethylsilyl)ethoxy]methyl}-1H-benzimidazol-6-yl)acetonitrile

: 886979-23-3
(6-[4-(ethylsulfonyl)phenoxy]-2-(pyridin-2-yl)-1-{[2-(trimethylsilyl)ethoxy]methyl}-1H-benzimidazol-5-yl)acetonitrile

: 886979-27-7
(6-[4-(ethylsulfonyl)phenoxy]-2-(pyridin-2-yl)-1-{[2-(trimethylsilyl)ethoxy]methyl}-1H-benzimidazol-5-yl)acetic acid

: 886982-98-5
(5-[4-(ethylsulfonyl)phenoxy]-2-(pyridin-2-yl)-1-{[2-(trimethylsilyl)ethoxy]methyl}-1H-benzimidazol-6-yl)acetic acid

Guidance literature:: (5-[4-(ethylsulfonyl)phenoxy]-2-(pyridin-2-yl)-1-{[2-(trimethylsilyl)ethoxy]methyl}-1H-benzimidazol-6-yl)acetonitrile; (6-[4-(ethylsulfonyl)phenoxy]-2-(pyridin-2-yl)-1-{[2-(trimethylsilyl)ethoxy]methyl}-1H-benzimidazol-5-yl)acetonitrile; With sodium hydroxide; ethanol; water; at 70 ℃;

With citric acid; In ethanol; water; at 0 ℃;

Reference yield:

: 773837-37-9
sodium cyanide

: 886976-80-3
methyl 5-[4-(ethylsulfonyl)phenoxy]-2-(pyridin-2-yl)-1H-benzimidazole-6-carboxylate

: 76513-69-4
(2-trimethylethylsilylethoxy)methyl chloride

: 886979-27-7
(6-[4-(ethylsulfonyl)phenoxy]-2-(pyridin-2-yl)-1-{[2-(trimethylsilyl)ethoxy]methyl}-1H-benzimidazol-5-yl)acetic acid

: 886982-98-5
(5-[4-(ethylsulfonyl)phenoxy]-2-(pyridin-2-yl)-1-{[2-(trimethylsilyl)ethoxy]methyl}-1H-benzimidazol-6-yl)acetic acid

Guidance literature:: methyl 5-[4-(ethylsulfonyl)phenoxy]-2-(pyridin-2-yl)-1H-benzimidazole-6-carboxylate; (2-trimethylethylsilylethoxy)methyl chloride; With sodium hydride; In N,N-dimethyl-formamide; paraffin oil; at 20 ℃; for 0.5h;

With lithium aluminium tetrahydride; In tetrahydrofuran; at 0 - 20 ℃;

sodium cyanide; Further stages;
DOI:10.1016/j.bmc.2009.05.037