(5-[4-(ethylsulfonyl)phenoxy]-2-(pyridin-2-yl)-1-{[2-(trimethylsilyl)ethoxy]methyl}-1H-benzimidazol-6-yl)acetonitrile

Base Information

Chemical Name:(5-[4-(ethylsulfonyl)phenoxy]-2-(pyridin-2-yl)-1-{[2-(trimethylsilyl)ethoxy]methyl}-1H-benzimidazol-6-yl)acetonitrile
CAS No.:886979-22-2
Molecular Formula:C₂₈H₃₂N₄O₄SSi
Molecular Weight:548.738
Hs Code.:

Synonyms:(5-[4-(ethylsulfonyl)phenoxy]-2-(pyridin-2-yl)-1-{[2-(trimethylsilyl)ethoxy]methyl}-1H-benzimidazol-6-yl)acetonitrile

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Chemical Property of (5-[4-(ethylsulfonyl)phenoxy]-2-(pyridin-2-yl)-1-{[2-(trimethylsilyl)ethoxy]methyl}-1H-benzimidazol-6-yl)acetonitrile

Chemical Property:

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Technology Process of (5-[4-(ethylsulfonyl)phenoxy]-2-(pyridin-2-yl)-1-{[2-(trimethylsilyl)ethoxy]methyl}-1H-benzimidazol-6-yl)acetonitrile

There total 3 articles about (5-[4-(ethylsulfonyl)phenoxy]-2-(pyridin-2-yl)-1-{[2-(trimethylsilyl)ethoxy]methyl}-1H-benzimidazol-6-yl)acetonitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 886976-81-4
(5-[4-(ethylsulfonyl)phenoxy]-2-(pyridin-2-yl)-1-{[2-(trimethylsilyl)ethoxy]methyl}-1H-benzimidazol-6-yl)methanol

: 143-33-9,25596-52-5
sodium cyanide

: 886979-22-2
(5-[4-(ethylsulfonyl)phenoxy]-2-(pyridin-2-yl)-1-{[2-(trimethylsilyl)ethoxy]methyl}-1H-benzimidazol-6-yl)acetonitrile

Guidance literature:: (5-[4-(ethylsulfonyl)phenoxy]-2-(pyridin-2-yl)-1-{[2-(trimethylsilyl)ethoxy]methyl}-1H-benzimidazol-6-yl)methanol; With methanesulfonyl chloride; triethylamine; In tetrahydrofuran; at 0 ℃; for 0.333333h;

sodium cyanide; In N,N-dimethyl-formamide; at 20 ℃; for 4h;

Reference yield:

: (6-[4-(ethylsulfonyl)phenoxy]-2-(pyridin-2-yl)-1-{[2-(trimethylsilyl)ethoxy]methyl}-1H-benzimidazol-5-yl)methylmethanesulfonate

: (5-[4-(ethylsulfonyl)phenoxy]-2-(pyridin-2-yl)-1-{[2-(trimethylsilyl)ethoxy]methyl}-1H-benzimidazol-6-yl)methyl methanesulfonate

: 143-33-9,25596-52-5
sodium cyanide

: 886979-22-2
(5-[4-(ethylsulfonyl)phenoxy]-2-(pyridin-2-yl)-1-{[2-(trimethylsilyl)ethoxy]methyl}-1H-benzimidazol-6-yl)acetonitrile

: 886979-23-3
(6-[4-(ethylsulfonyl)phenoxy]-2-(pyridin-2-yl)-1-{[2-(trimethylsilyl)ethoxy]methyl}-1H-benzimidazol-5-yl)acetonitrile

Guidance literature:: In N,N-dimethyl-formamide; at 0 - 20 ℃; for 3h;

Reference yield:

: 773837-37-9
sodium cyanide

: 886976-80-3
methyl 5-[4-(ethylsulfonyl)phenoxy]-2-(pyridin-2-yl)-1H-benzimidazole-6-carboxylate

: 76513-69-4
(2-trimethylethylsilylethoxy)methyl chloride

: 886979-22-2
(5-[4-(ethylsulfonyl)phenoxy]-2-(pyridin-2-yl)-1-{[2-(trimethylsilyl)ethoxy]methyl}-1H-benzimidazol-6-yl)acetonitrile

: 886979-23-3
(6-[4-(ethylsulfonyl)phenoxy]-2-(pyridin-2-yl)-1-{[2-(trimethylsilyl)ethoxy]methyl}-1H-benzimidazol-5-yl)acetonitrile

Guidance literature:: methyl 5-[4-(ethylsulfonyl)phenoxy]-2-(pyridin-2-yl)-1H-benzimidazole-6-carboxylate; (2-trimethylethylsilylethoxy)methyl chloride; With sodium hydride; In N,N-dimethyl-formamide; paraffin oil; at 20 ℃; for 0.5h;

With lithium aluminium tetrahydride; In tetrahydrofuran; at 0 - 20 ℃;

sodium cyanide; Further stages;
DOI:10.1016/j.bmc.2009.05.037