tert-butyl (E)-4-[2-[2-(4-methanesulfonylphenyl)vinyl]pyridin-5-yl]piperidine-1-carboxylate

Base Information

Chemical Name:tert-butyl (E)-4-[2-[2-(4-methanesulfonylphenyl)vinyl]pyridin-5-yl]piperidine-1-carboxylate
CAS No.:1206968-47-9
Molecular Formula:C₂₄H₃₀N₂O₄S
Molecular Weight:442.579
Hs Code.:

Synonyms:tert-butyl (E)-4-[2-[2-(4-methanesulfonylphenyl)vinyl]pyridin-5-yl]piperidine-1-carboxylate

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Chemical Property of tert-butyl (E)-4-[2-[2-(4-methanesulfonylphenyl)vinyl]pyridin-5-yl]piperidine-1-carboxylate

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Technology Process of tert-butyl (E)-4-[2-[2-(4-methanesulfonylphenyl)vinyl]pyridin-5-yl]piperidine-1-carboxylate

There total 6 articles about tert-butyl (E)-4-[2-[2-(4-methanesulfonylphenyl)vinyl]pyridin-5-yl]piperidine-1-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 5398-77-6
para-methanesulfonylbenzaldehyde

: C₁₆H₂₃BrN₂O₂

: 1206968-47-9
tert-butyl (E)-4-[2-[2-(4-methanesulfonylphenyl)vinyl]pyridin-5-yl]piperidine-1-carboxylate

Guidance literature:: C₁₆H₂₃BrN₂O₂; With triethyl phosphite; at 150 ℃; for 1h;

With sodium hydride; In tetrahydrofuran; mineral oil; at 20 ℃; for 1h; Cooling with ice; Inert atmosphere;

para-methanesulfonylbenzaldehyde; In tetrahydrofuran; mineral oil; at 20 ℃; for 2h;

Reference yield:

: 286961-15-7
benzyl 4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-3,6-dihydro-1 (2H)-pyridinecarboxylate

: 1206968-47-9
tert-butyl (E)-4-[2-[2-(4-methanesulfonylphenyl)vinyl]pyridin-5-yl]piperidine-1-carboxylate

Guidance literature:: Multi-step reaction with 5 steps

1.1: caesium carbonate / dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂ / N,N-dimethyl-formamide; tetrahydrofuran / 2.5 h / 90 °C / Inert atmosphere

2.1: hydrogen / palladium 10% on activated carbon / methanol / 17 h / 20 °C

3.1: triethylamine / water; tetrahydrofuran / 0.17 h / 20 °C

4.1: carbon tetrabromide; triphenylphosphine / dichloromethane / 1 h / 0 °C / Inert atmosphere

5.1: triethyl phosphite / 1 h / 150 °C

5.2: 1 h / 20 °C / Cooling with ice; Inert atmosphere

5.3: 2 h / 20 °C

With carbon tetrabromide; hydrogen; caesium carbonate; triethylamine; triphenylphosphine; triethyl phosphite; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; palladium 10% on activated carbon; In tetrahydrofuran; methanol; dichloromethane; water; N,N-dimethyl-formamide;

Reference yield:

: 1206968-55-9
Benzyl 4-[2-(hydroxymethyl) pyridin-5-yl]-3, 6-dihydro-2H-pyridine-1-carboxylate

: 1206968-47-9
tert-butyl (E)-4-[2-[2-(4-methanesulfonylphenyl)vinyl]pyridin-5-yl]piperidine-1-carboxylate

Guidance literature:: Multi-step reaction with 4 steps

1.1: hydrogen / palladium 10% on activated carbon / methanol / 17 h / 20 °C

2.1: triethylamine / water; tetrahydrofuran / 0.17 h / 20 °C

3.1: carbon tetrabromide; triphenylphosphine / dichloromethane / 1 h / 0 °C / Inert atmosphere

4.1: triethyl phosphite / 1 h / 150 °C

4.2: 1 h / 20 °C / Cooling with ice; Inert atmosphere

4.3: 2 h / 20 °C

With carbon tetrabromide; hydrogen; triethylamine; triphenylphosphine; triethyl phosphite; palladium 10% on activated carbon; In tetrahydrofuran; methanol; dichloromethane; water;