cyclopropyl-[4-(4-methoxy-phenyl)-piperidin-1-yl]-methanone

Base Information

• Chemical Name: cyclopropyl-[4-(4-methoxy-phenyl)-piperidin-1-yl]-methanone
• CAS No.: 1276045-15-8
• Molecular Formula: C₁₆H₂₁NO₂
• Molecular Weight: 259.348
• Mol file: 1276045-15-8.mol

Synonyms:cyclopropyl-[4-(4-methoxy-phenyl)-piperidin-1-yl]-methanone

Chemical Property of cyclopropyl-[4-(4-methoxy-phenyl)-piperidin-1-yl]-methanone

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of cyclopropyl-[4-(4-methoxy-phenyl)-piperidin-1-yl]-methanone

There total 3 articles about cyclopropyl-[4-(4-methoxy-phenyl)-piperidin-1-yl]-methanone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

4-(4-methoxy-phenyl)-piperidine trifluoroacetate + cyclopropanecarboxylic acid chloride (4023-34-1) → cyclopropyl-[4-(4-methoxy-phenyl)-piperidin-1-yl]-methanone (1276045-15-8)

Guidance literature:

With triethylamine; In dichloromethane; at 0 - 20 ℃;

DOI:10.1016/j.bmcl.2010.12.068

Reference yield:

4-(4-methoxyphenyl)-3,6-dihydro-2H-pyridine-1-carboxylic acid tert-butyl ester (138647-51-5) → cyclopropyl-[4-(4-methoxy-phenyl)-piperidin-1-yl]-methanone (1276045-15-8)

Guidance literature:

Multi-step reaction with 3 steps

1: 10% palladium on activated charcoal; hydrogen / ethanol

2: dichloromethane / 0 °C

3: triethylamine / dichloromethane / 0 - 20 °C

With 10% palladium on activated charcoal; hydrogen; triethylamine; In ethanol; dichloromethane;

DOI:10.1016/j.bmcl.2010.12.068

Reference yield:

tert-butyl 4-(4-methoxyphenyl)piperidine-1-carboxylate (303975-71-5) → cyclopropyl-[4-(4-methoxy-phenyl)-piperidin-1-yl]-methanone (1276045-15-8)

Guidance literature:

Multi-step reaction with 2 steps

1: dichloromethane / 0 °C

2: triethylamine / dichloromethane / 0 - 20 °C

With triethylamine; In dichloromethane;

DOI:10.1016/j.bmcl.2010.12.068

upstream raw materials:

cyclopropanecarboxylic acid chloride

4-(4-methoxyphenyl)-3,6-dihydro-2H-pyridine-1-carboxylic acid tert-butyl ester

tert-butyl 4-(4-methoxyphenyl)piperidine-1-carboxylate