138647-51-5

Basic information

• Product Name: 1(2H)-Pyridinecarboxylic acid, 3,6-dihydro-4-(4-methoxyphenyl)-, 1,1-dimethylethyl ester
• CAS NO: 138647-51-5
• Molecular Formula: C17H23NO3
• Molecular Weight: 289.375
• Mol File: 138647-51-5.mol
• Article Data: 14

Chemical Properties

• CAS DataBase Reference: 1(2H)-Pyridinecarboxylic acid, 3,6-dihydro-4-(4-methoxyphenyl)-, 1,1-dimethylethyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: 1(2H)-Pyridinecarboxylic acid, 3,6-dihydro-4-(4-methoxyphenyl)-, 1,1-dimethylethyl ester(138647-51-5)
• EPA Substance Registry System: 1(2H)-Pyridinecarboxylic acid, 3,6-dihydro-4-(4-methoxyphenyl)-, 1,1-dimethylethyl ester(138647-51-5)

Safety Data

• Hazardous Substances Data: 138647-51-5(Hazardous Substances Data)

Usage

General Description

1(2H)-Pyridinecarboxylic acid, 3,6-dihydro-4-(4-methoxyphenyl)-, 1,1-dimethylethyl ester, also known as telmisartan, is a medication used to treat high blood pressure, heart failure, and diabetic kidney disease. It belongs to the angiotensin II receptor blocker (ARB) class of drugs, which work by blocking the action of a hormone called angiotensin II, leading to blood vessel dilation and reduced blood pressure. Telmisartan is typically taken orally and may be prescribed in combination with other antihypertensive medications. It is available in tablet form and is generally well-tolerated, with common side effects including dizziness, headache, and diarrhea. As with any medication, it is important to follow the prescribed dosage and directions for use.

Upstream product

• 5720-07-0 4-methoxyphenylboronic acid 
• 138647-49-1 4-Trifluoromethanesulfonyloxy-3,6-dihydro-2H-pyridine-1-carboxylic acid tert-butyl ester 
• 328-70-1 3,6-bis(trifluoromethyl)bromobenzene 
• 375853-82-0 tert-Butyl 4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-3,6-dihydro-1(2H)-pyridinecarboxylate 
• 13139-86-1 4-methoxyphenyl magnesium bromide 
• 79099-07-3 N-tert-butyloxycarbonylpiperidin-4-one 
• 302924-67-0 tert-butyl 4-hydroxy-4-(4-methoxyphenyl)-1-piperidinecarboxylate 
• 104-92-7 1-bromo-4-methoxy-benzene 

Downstream Products

• 1276045-15-8 cyclopropyl-[4-(4-methoxy-phenyl)-piperidin-1-yl]-methanone 
• 1276045-16-9 1-[4-(4-methoxy-phenyl)-piperidin-1-yl]-ethanone 
• 303975-71-5 tert-butyl 4-(4-methoxyphenyl)piperidine-1-carboxylate 
• 1574730-89-4 2-(2-(4-(4-methoxyphenyl)-5,6-dihydropyridin-1(2H)-yl)ethyl)isoindoline-1,3-dione 
• 1574730-64-5 2-(4-(4-methoxyphenyl)-5,6-dihydropyridin-1(2H)-yl)ethanamine 
• 1394387-87-1 N-((3-isopropylisoxazol-5-yl)methyl)-2-(4-(4-methoxyphenyl)-5,6-dihydropyridin-1(2H)-yl)ethanamine 
• 59954-73-3 4-(4-methoxyphenyl)-1,2,3,6-tetrahydro-pyridine 
• 725739-54-8 4-(4-methoxy-phenyl)-3,6-dihydro-2H-pyridine-1-sulfonyl chloride 

Relevant articles and documents

A versatile synthesis of 4-aryl tetrahydropyridines via palladium mediated Suzuki cross-coupling with cyclic vinyl boronates

A simple preparation of cyclic vinyl boronates derived from the vinyl triflates of N-protected tetrahydropyridines is described. Suzuki coupling of the boronates with aryl bromides, iodides and triflates proceeds in good yield to give 4-aryl tetrahydropyridines. (C) 2000 Elsevier Science Ltd.

20-HETE FORMATION INHIBITORS

This disclosure provides novel heterocyclic compounds and methods for inhibiting the enzyme CYP4. Further disclosed methods include: a method of inhibiting the biosynthesis of 20-hydroxyeicosatetraenoic acid (20-HETE) in a subject in need thereof and a method of producing neuroprotection and decreased brain damage by preventing cerebral microvascular blood flow impairment and anti-oxidant mechanisms in a subject experiencing or having experienced an ischemic event.

Catalytic Friedel-Crafts Reactions on Saturated Heterocycles and Small Rings for sp3-sp2 Coupling of Medicinally Relevant Fragments

gem-Diarylheterocycles display a wide range of biological activity. Here we present a systematic study into the formation of 4- to 6-membered O- and N-heterocycles and cyclobutanes bearing the diaryl motif through a catalytic Friedel–Crafts reaction from the corresponding benzylic alcohols. 3,3-Diaryltetrahydrofurans, 4,4-diaryltetrahydropyrans, 3,3-diarylpyrrolidines, 4,4-diaryl-piperidines, as well as diarylcyclobutanes are examined, with results for 3,3-diaryloxetanes and 3,3-diarylazetidines presented for comparison. Three catalytic systems are investigated for each substrate [Ca(II), Li(I) and Fe(III)], across preinstalled aromatic groups of differing electronic character. In most cases examined, the diaryl product is obtained directly from the alcohol with good yields using the most appropriate catalyst system. In the absence of a nucleophile, the olefins from the 5- and 6-membered substrates by elimination of water are obtained under the same reaction conditions.