5-(4-hydroxybenzyl)-3-phenyl-1,4,5,6-tetrahydro-1,2,4-triazin-6(5H)-one

Base Information

Chemical Name:5-(4-hydroxybenzyl)-3-phenyl-1,4,5,6-tetrahydro-1,2,4-triazin-6(5H)-one
CAS No.:1337535-19-9
Molecular Formula:C₁₆H₁₅N₃O₂
Molecular Weight:281.314
Hs Code.:

Synonyms:5-(4-hydroxybenzyl)-3-phenyl-1,4,5,6-tetrahydro-1,2,4-triazin-6(5H)-one

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 5-(4-hydroxybenzyl)-3-phenyl-1,4,5,6-tetrahydro-1,2,4-triazin-6(5H)-one

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Technology Process of 5-(4-hydroxybenzyl)-3-phenyl-1,4,5,6-tetrahydro-1,2,4-triazin-6(5H)-one

There total 3 articles about 5-(4-hydroxybenzyl)-3-phenyl-1,4,5,6-tetrahydro-1,2,4-triazin-6(5H)-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 71.0%

: 7662-51-3
L-tyrosine hydrazide

: 1663-61-2
triethoxymethylbenzene

: 1337535-19-9
5-(4-hydroxybenzyl)-3-phenyl-1,4,5,6-tetrahydro-1,2,4-triazin-6(5H)-one

Guidance literature:: With toluene-4-sulfonic acid; In 5,5-dimethyl-1,3-cyclohexadiene; for 3h; Reflux;
DOI:10.1016/j.tet.2011.07.047

Reference yield:

: 3417-91-2
L-tyrosine methyl ester HCl

: 1337535-19-9
5-(4-hydroxybenzyl)-3-phenyl-1,4,5,6-tetrahydro-1,2,4-triazin-6(5H)-one

Guidance literature:: Multi-step reaction with 2 steps

1: hydrazine hydrate / methanol / 24 h

2: toluene-4-sulfonic acid / 5,5-dimethyl-1,3-cyclohexadiene / 3 h / Reflux

With toluene-4-sulfonic acid; hydrazine hydrate; In methanol; 5,5-dimethyl-1,3-cyclohexadiene;
DOI:10.1016/j.tet.2011.07.047

Reference yield:

: 60-18-4,18875-48-4,25619-78-7,30704-25-7
L-tyrosine

: 1337535-19-9
5-(4-hydroxybenzyl)-3-phenyl-1,4,5,6-tetrahydro-1,2,4-triazin-6(5H)-one

Guidance literature:: Multi-step reaction with 3 steps

1: thionyl chloride / 6 h / 0 °C

2: hydrazine hydrate / methanol / 24 h

3: toluene-4-sulfonic acid / 5,5-dimethyl-1,3-cyclohexadiene / 3 h / Reflux

With thionyl chloride; toluene-4-sulfonic acid; hydrazine hydrate; In methanol; 5,5-dimethyl-1,3-cyclohexadiene;
DOI:10.1016/j.tet.2011.07.047