tert-butyl (2S)-2-[(1R,2R)-1-methoxy-2-methyl-3-{[(1S)-2-phenyl-1-(1,3-thiazol-2-yl)ethyl]amino}-3-thioxopropyl]pyrrolidine-1-carboxylate

Base Information

Chemical Name:tert-butyl (2S)-2-[(1R,2R)-1-methoxy-2-methyl-3-{[(1S)-2-phenyl-1-(1,3-thiazol-2-yl)ethyl]amino}-3-thioxopropyl]pyrrolidine-1-carboxylate
CAS No.:1438851-43-4
Molecular Formula:C₂₅H₃₅N₃O₃S₂
Molecular Weight:489.703
Hs Code.:

Synonyms:tert-butyl (2S)-2-[(1R,2R)-1-methoxy-2-methyl-3-{[(1S)-2-phenyl-1-(1,3-thiazol-2-yl)ethyl]amino}-3-thioxopropyl]pyrrolidine-1-carboxylate

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Chemical Property of tert-butyl (2S)-2-[(1R,2R)-1-methoxy-2-methyl-3-{[(1S)-2-phenyl-1-(1,3-thiazol-2-yl)ethyl]amino}-3-thioxopropyl]pyrrolidine-1-carboxylate

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Technology Process of tert-butyl (2S)-2-[(1R,2R)-1-methoxy-2-methyl-3-{[(1S)-2-phenyl-1-(1,3-thiazol-2-yl)ethyl]amino}-3-thioxopropyl]pyrrolidine-1-carboxylate

There total 11 articles about tert-butyl (2S)-2-[(1R,2R)-1-methoxy-2-methyl-3-{[(1S)-2-phenyl-1-(1,3-thiazol-2-yl)ethyl]amino}-3-thioxopropyl]pyrrolidine-1-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 33.0%

tert-butyl (2S)-2-[(1R,2R)-1-methoxy-2-methyl-3-oxo-3-{[(1S)-2-phenyl-1-(1,3-thiazol-2-yl)ethyl]amino}propyl]pyrrolidine-1-carboxylate: 120205-54-1
tert-butyl (2S)-2-[(1R,2R)-1-methoxy-2-methyl-3-oxo-3-{[(1S)-2-phenyl-1-(1,3-thiazol-2-yl)ethyl]amino}propyl]pyrrolidine-1-carboxylate

: 1438851-43-4
tert-butyl (2S)-2-[(1R,2R)-1-methoxy-2-methyl-3-{[(1S)-2-phenyl-1-(1,3-thiazol-2-yl)ethyl]amino}-3-thioxopropyl]pyrrolidine-1-carboxylate

Guidance literature:: With Lawessons reagent; In toluene; at 100 ℃; for 0.166667h;

Reference yield:

: 19172-47-5,94367-93-8
Lawessons reagent

: 1438851-43-4
tert-butyl (2S)-2-[(1R,2R)-1-methoxy-2-methyl-3-{[(1S)-2-phenyl-1-(1,3-thiazol-2-yl)ethyl]amino}-3-thioxopropyl]pyrrolidine-1-carboxylate

Guidance literature:: In n-heptane; ethyl acetate; toluene;

Reference yield:

: 69610-41-9,117625-90-8
Boc-L-Pro-H

: 1438851-43-4
tert-butyl (2S)-2-[(1R,2R)-1-methoxy-2-methyl-3-{[(1S)-2-phenyl-1-(1,3-thiazol-2-yl)ethyl]amino}-3-thioxopropyl]pyrrolidine-1-carboxylate

Guidance literature:: Multi-step reaction with 5 steps

1.1: tetrabutylammomium bromide / dichloromethane; water / 13 h

2.1: sodium hydride / mineral oil; hexane; N,N-dimethyl-formamide / 2 h / 0 - 5 °C

3.1: osmium(VIII) oxide; 4-methylmorpholine N-oxide / water; tert-butyl alcohol / 12 h

3.2: 4 h / 0 - 5 °C

4.1: diethyl cyanophosphonate; triethylamine / N,N-dimethyl-formamide / 20 h / 0 - 20 °C

5.1: Lawessons reagent / toluene / 0.17 h / 100 °C

With Lawessons reagent; osmium(VIII) oxide; diethyl cyanophosphonate; tetrabutylammomium bromide; sodium hydride; 4-methylmorpholine N-oxide; triethylamine; In hexane; dichloromethane; water; N,N-dimethyl-formamide; toluene; mineral oil; tert-butyl alcohol;