rac-N-(1-hydroxy-3-phenylpropan-2-yl)acetamide

Base Information

• Chemical Name: rac-N-(1-hydroxy-3-phenylpropan-2-yl)acetamide
• CAS No.: 19881-92-6
• Molecular Formula: C₁₁H₁₅NO₂
• Molecular Weight: 193.246
• Mol file: 19881-92-6.mol

Synonyms:rac-N-(1-hydroxy-3-phenylpropan-2-yl)acetamide

Chemical Property of rac-N-(1-hydroxy-3-phenylpropan-2-yl)acetamide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of rac-N-(1-hydroxy-3-phenylpropan-2-yl)acetamide

There total 17 articles about rac-N-(1-hydroxy-3-phenylpropan-2-yl)acetamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 97.0%

rac-phenylalaninol (1795-98-8,3182-95-4,5267-64-1,16088-07-6) + acetic anhydride (108-24-7) → rac-N-(1-hydroxy-3-phenylpropan-2-yl)acetamide (19881-92-6)

Guidance literature:

With sodium hydroxide; In water; isopropyl alcohol; for 0.5h; Ambient temperature;

DOI:10.1080/00397919208021671

Reference yield: 75.0%

2-(hydroxyimino)-3-phenylpropyl acetate → rac-N-(1-hydroxy-3-phenylpropan-2-yl)acetamide (19881-92-6)

Guidance literature:

2-(hydroxyimino)-3-phenylpropyl acetate; With hydrogen; In methanol; at 60 ℃; for 4h; under 30003 Torr; Autoclave;

In toluene; for 1h; Reflux; Autoclave;

DOI:10.1002/ejoc.201701266

Reference yield:

2-(N-acetylamino)cinnamic acid (55065-02-6,64590-80-3,5469-45-4) → rac-N-(1-hydroxy-3-phenylpropan-2-yl)acetamide (19881-92-6)

Guidance literature:

With D-Glucose; Escherichia coli endogenous alcohol dehydrogenase; Segniliparus rugosus carboxylic acid reductase; dimethyl sulfoxide; magnesium chloride; In aq. phosphate buffer; at 30 ℃; for 18h; pH=7.5; Enzymatic reaction;

DOI:10.1039/d0gc00867b

upstream raw materials:

ethyl N-acetyl-DL-phenylalaninate

(R,S)-N-acetyl phenylalanine

rac-phenylalaninol

acetic anhydride

Downstream raw materials:

(R,S)-N-acetyl phenylalanine