2-cyclopropyl-4-(4-fluorophenyl)-3-iodoquinoline

Base Information

• Chemical Name: 2-cyclopropyl-4-(4-fluorophenyl)-3-iodoquinoline
• CAS No.: 153968-97-9
• Molecular Formula: C₁₈H₁₃FIN
• Molecular Weight: 389.211
• Mol file: 153968-97-9.mol

Synonyms:2-cyclopropyl-4-(4-fluorophenyl)-3-iodoquinoline

Chemical Property of 2-cyclopropyl-4-(4-fluorophenyl)-3-iodoquinoline

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 2-cyclopropyl-4-(4-fluorophenyl)-3-iodoquinoline

There total 11 articles about 2-cyclopropyl-4-(4-fluorophenyl)-3-iodoquinoline which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 35.0%

1-fluoro-4-(iodoethynyl)benzene (1246224-43-0) + benzenediazonium tetrafluoroborate (369-57-3) + cyclopropropanecarbonitrile (5500-21-0) → 2-cyclopropyl-4-(4-fluorophenyl)-3-iodoquinoline (153968-97-9)

Guidance literature:

at 80 ℃; for 2h; regiospecific reaction; Sealed tube; Green chemistry;

DOI:10.1016/j.tet.2017.05.085

Reference yield:

2-Cyclopropyl-4-(4-fluoro-phenyl)-quinoline-3-carboxylic acid (160375-37-1) → 2-cyclopropyl-4-(4-fluorophenyl)-3-iodoquinoline (153968-97-9)

Guidance literature:

With [bis(acetoxy)iodo]benzene; iodine; In tetrachloromethane; Yield given; Heating;

DOI:10.1016/S0040-4039(00)61407-7

Reference yield:

Cyclopropyl methyl ketone (765-43-5) → 2-cyclopropyl-4-(4-fluorophenyl)-3-iodoquinoline (153968-97-9)

Guidance literature:

Multi-step reaction with 4 steps

1: 85 percent

2: 90 percent / PTS

3: KOH / dioxane; H₂O

4: I₂, PhI(OAc)2 / CCl₄ / Heating

With potassium hydroxide; [bis(acetoxy)iodo]benzene; iodine; pyridinium p-toluenesulfonate; In 1,4-dioxane; tetrachloromethane; water;

DOI:10.1016/S0040-4039(00)61407-7

upstream raw materials:

2-Cyclopropyl-4-(4-fluoro-phenyl)-quinoline-3-carboxylic acid

Cyclopropyl methyl ketone

2-(toluene-4-sulfonylamino)-benzoic acid

2-amino-4'-fluorobenzophenone

Downstream raw materials:

(4R,6S)-(E)-{6-[2-(2-cyclopropyl-4-(4-fluorophenyl)quinolin-3-yl)-vinyl]-2,2-dimethyl-1,3-dioxan-4-yl}acetic acid tert-butyl ester