Technology Process of tetraethyl 2-[(3R,5R)-3-butyl-3-ethyl-7-(methyloxy)-1,1-dioxido-5-phenyl-2,3,4,5-tetrahydro-1,4-benzothiazepin-8-yl]-1,1,3,3-propanetetracarboxylate
There total 6 articles about tetraethyl 2-[(3R,5R)-3-butyl-3-ethyl-7-(methyloxy)-1,1-dioxido-5-phenyl-2,3,4,5-tetrahydro-1,4-benzothiazepin-8-yl]-1,1,3,3-propanetetracarboxylate which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
diethyl malonate;
With
ethanol; sodium ethanolate;
at 20 ℃;
for 0.333333h;
diethyl {[(3R,5R)-3-butyl-3-ethyl-7-(methyloxy)-1,1-dioxido-5-phenyl-2,3,4,5-tetrahydro-1,4-benzothiazepin-8-yl]methylidene}propanedioate;
In
ethanol;
at 20 ℃;
With
acetic acid;
In
ethanol;
pH=3 - 4;
- Guidance literature:
-
Multi-step reaction with 6 steps
1.1: hydrogenchloride; aluminum (III) chloride / 1,2-dichloro-ethane / 2.5 h / 20 °C
1.2: Cooling with ice
2.1: pyridine / dichloromethane / 0.5 h / 0 - 10 °C / Inert atmosphere
3.1: zinc / 1,1'-bis-(diphenylphosphino)ferrocene; tris-(dibenzylideneacetone)dipalladium(0) / N,N-dimethyl-formamide / 8.25 h / 20 - 80 °C / Inert atmosphere
4.1: diisobutylaluminium hydride / dichloromethane; toluene / 1 h / 0 °C
4.2: 1 h / Cooling with ice
5.1: piperidine / toluene / 100 °C
6.1: sodium ethanolate; ethanol / 0.33 h / 20 °C
6.2: 20 °C
6.3: pH 3 - 4
With
piperidine; pyridine; hydrogenchloride; aluminum (III) chloride; ethanol; sodium ethanolate; diisobutylaluminium hydride; zinc;
1,1'-bis-(diphenylphosphino)ferrocene; tris-(dibenzylideneacetone)dipalladium(0);
In
dichloromethane; 1,2-dichloro-ethane; N,N-dimethyl-formamide; toluene;
- Guidance literature:
-
Multi-step reaction with 5 steps
1.1: pyridine / dichloromethane / 0.5 h / 0 - 10 °C / Inert atmosphere
2.1: zinc / 1,1'-bis-(diphenylphosphino)ferrocene; tris-(dibenzylideneacetone)dipalladium(0) / N,N-dimethyl-formamide / 8.25 h / 20 - 80 °C / Inert atmosphere
3.1: diisobutylaluminium hydride / dichloromethane; toluene / 1 h / 0 °C
3.2: 1 h / Cooling with ice
4.1: piperidine / toluene / 100 °C
5.1: sodium ethanolate; ethanol / 0.33 h / 20 °C
5.2: 20 °C
5.3: pH 3 - 4
With
piperidine; pyridine; ethanol; sodium ethanolate; diisobutylaluminium hydride; zinc;
1,1'-bis-(diphenylphosphino)ferrocene; tris-(dibenzylideneacetone)dipalladium(0);
In
dichloromethane; N,N-dimethyl-formamide; toluene;
![diethyl {[(3R,5R)-3-butyl-3-ethyl-7-(methyloxy)-1,1-dioxido-5-phenyl-2,3,4,5-tetrahydro-1,4-benzothiazepin-8-yl]methylidene}propanedioate](/Databaselist/images/loading.webp)
