Technology Process of (2S,3S,4R)-3,4-Epoxy-4-(3-methoxyphenyl)-2-<(triisopropylsilyl)oxy>butane
There total 6 articles about (2S,3S,4R)-3,4-Epoxy-4-(3-methoxyphenyl)-2-<(triisopropylsilyl)oxy>butane which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
With
triethylamine;
In
dichloromethane;
at -60 ℃;
for 6h;
DOI:10.1021/jo00002a048
- Guidance literature:
-
Multi-step reaction with 5 steps
1: 96 percent / cerium(III) chloride heptahydrate, NaBH4 / methanol / 1.) -78 deg C, 15 min; 2.) room temp., 30 min
2: 48 percent / L-(+)-diisopropyl tartrate, titanium tetraisopropoxide, 3.0 M tert-butyl hydroperoxide / CH2Cl2; 2,2,4-trimethyl-pentane / 3 h / -20 °C
3: triphenylphosphine, diethyl azodicarboxylate / benzene; tetrahydrofuran / 1 h / Ambient temperature
4: anhydr. K2CO3 / methanol / 6 h / Ambient temperature
5: 87 percent / triethylamine / CH2Cl2 / 6 h / -60 °C
With
titanium(IV) isopropylate; tert.-butylhydroperoxide; sodium tetrahydroborate; cerium(III) chloride; L-(+)-diisopropyl tartrate; potassium carbonate; triethylamine; triphenylphosphine; diethylazodicarboxylate;
In
tetrahydrofuran; methanol; 2,2,4-trimethylpentane; dichloromethane; benzene;
DOI:10.1021/jo00002a048
- Guidance literature:
-
Multi-step reaction with 4 steps
1: 48 percent / L-(+)-diisopropyl tartrate, titanium tetraisopropoxide, 3.0 M tert-butyl hydroperoxide / CH2Cl2; 2,2,4-trimethyl-pentane / 3 h / -20 °C
2: triphenylphosphine, diethyl azodicarboxylate / benzene; tetrahydrofuran / 1 h / Ambient temperature
3: anhydr. K2CO3 / methanol / 6 h / Ambient temperature
4: 87 percent / triethylamine / CH2Cl2 / 6 h / -60 °C
With
titanium(IV) isopropylate; tert.-butylhydroperoxide; L-(+)-diisopropyl tartrate; potassium carbonate; triethylamine; triphenylphosphine; diethylazodicarboxylate;
In
tetrahydrofuran; methanol; 2,2,4-trimethylpentane; dichloromethane; benzene;
DOI:10.1021/jo00002a048
