6-(3-chloro-2-fluoro-phenyl)-2-(3-piperidin-1-yl-propoxy)-5H-pyrazolo[1,5-a]pyrazin-4-one

Base Information

Chemical Name:6-(3-chloro-2-fluoro-phenyl)-2-(3-piperidin-1-yl-propoxy)-5H-pyrazolo[1,5-a]pyrazin-4-one
CAS No.:1192313-65-7
Molecular Formula:C₂₀H₂₂ClFN₄O₂
Molecular Weight:404.872
Hs Code.:

Synonyms:6-(3-chloro-2-fluoro-phenyl)-2-(3-piperidin-1-yl-propoxy)-5H-pyrazolo[1,5-a]pyrazin-4-one

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Chemical Property of 6-(3-chloro-2-fluoro-phenyl)-2-(3-piperidin-1-yl-propoxy)-5H-pyrazolo[1,5-a]pyrazin-4-one

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Technology Process of 6-(3-chloro-2-fluoro-phenyl)-2-(3-piperidin-1-yl-propoxy)-5H-pyrazolo[1,5-a]pyrazin-4-one

There total 6 articles about 6-(3-chloro-2-fluoro-phenyl)-2-(3-piperidin-1-yl-propoxy)-5H-pyrazolo[1,5-a]pyrazin-4-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: C₂₀H₂₄ClFN₄O₃

: 1192313-65-7
6-(3-chloro-2-fluoro-phenyl)-2-(3-piperidin-1-yl-propoxy)-5H-pyrazolo[1,5-a]pyrazin-4-one

Guidance literature:: C₂₀H₂₄ClFN₄O₃; With acetic acid; Heating; Reflux;

With sodium hydroxide;

Reference yield:

: 2-bromo-1-(3-chloro-2-fluorophenyl)ethan-1-one

: 1192313-65-7
6-(3-chloro-2-fluoro-phenyl)-2-(3-piperidin-1-yl-propoxy)-5H-pyrazolo[1,5-a]pyrazin-4-one

Guidance literature:: Multi-step reaction with 4 steps

1.1: potassium carbonate / N,N-dimethyl-formamide / 0.25 h / 20 °C

1.2: 20 °C

2.1: ammonium acetate; acetic acid / Heating; Reflux

3.1: acetic acid / Heating; Reflux

4.1: acetic acid / Heating; Reflux

With ammonium acetate; potassium carbonate; acetic acid; In N,N-dimethyl-formamide;

Reference yield:

: 161957-59-1
1-(3-chloro-2-fluorophenyl)ethan-1-one

: 1192313-65-7
6-(3-chloro-2-fluoro-phenyl)-2-(3-piperidin-1-yl-propoxy)-5H-pyrazolo[1,5-a]pyrazin-4-one

Guidance literature:: Multi-step reaction with 5 steps

1.1: bromine / 1,4-dioxane / 20 °C

2.1: potassium carbonate / N,N-dimethyl-formamide / 0.25 h / 20 °C

2.2: 20 °C

3.1: ammonium acetate; acetic acid / Heating; Reflux

4.1: acetic acid / Heating; Reflux

5.1: acetic acid / Heating; Reflux

With ammonium acetate; bromine; potassium carbonate; acetic acid; In 1,4-dioxane; N,N-dimethyl-formamide;