2-[6-(3-chloro-2-fluorophenyl)-4-oxo-2-{[3-(1-piperidinyl)propyl]oxy}pyrazolo[1,5-a]pyrazin-5(4H)-yl]-N-(1-methylethyl)acetamide hydrochloride salt

Base Information

• Chemical Name: 2-[6-(3-chloro-2-fluorophenyl)-4-oxo-2-{[3-(1-piperidinyl)propyl]oxy}pyrazolo[1,5-a]pyrazin-5(4H)-yl]-N-(1-methylethyl)acetamide hydrochloride salt
• CAS No.: 1192313-10-2
• Molecular Formula: C₂₅H₃₁ClFN₅O₃*ClH
• Molecular Weight: 540.465
• Mol file: 1192313-10-2.mol

Synonyms:2-[6-(3-chloro-2-fluorophenyl)-4-oxo-2-{[3-(1-piperidinyl)propyl]oxy}pyrazolo[1,5-a]pyrazin-5(4H)-yl]-N-(1-methylethyl)acetamide hydrochloride salt

Chemical Property of 2-[6-(3-chloro-2-fluorophenyl)-4-oxo-2-{[3-(1-piperidinyl)propyl]oxy}pyrazolo[1,5-a]pyrazin-5(4H)-yl]-N-(1-methylethyl)acetamide hydrochloride salt

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2-[6-(3-chloro-2-fluorophenyl)-4-oxo-2-{[3-(1-piperidinyl)propyl]oxy}pyrazolo[1,5-a]pyrazin-5(4H)-yl]-N-(1-methylethyl)acetamide hydrochloride salt

There total 7 articles about 2-[6-(3-chloro-2-fluorophenyl)-4-oxo-2-{[3-(1-piperidinyl)propyl]oxy}pyrazolo[1,5-a]pyrazin-5(4H)-yl]-N-(1-methylethyl)acetamide hydrochloride salt which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

2-chloro-N-isopropylacetamide (2895-21-8) + 6-(3-chloro-2-fluoro-phenyl)-2-(3-piperidin-1-yl-propoxy)-5H-pyrazolo[1,5-a]pyrazin-4-one (1192313-65-7) → 2-[6-(3-chloro-2-fluorophenyl)-4-oxo-2-{[3-(1-piperidinyl)propyl]oxy}pyrazolo[1,5-a]pyrazin-5(4H)-yl]-N-(1-methylethyl)acetamide hydrochloride salt (1192313-10-2)

Guidance literature:

2-chloro-N-isopropylacetamide; 6-(3-chloro-2-fluoro-phenyl)-2-(3-piperidin-1-yl-propoxy)-5H-pyrazolo[1,5-a]pyrazin-4-one; With potassium carbonate; In N,N-dimethyl-formamide; at 20 - 60 ℃;

With hydrogenchloride; In diethyl ether; dichloromethane; at 0 ℃; for 0.5h;

Reference yield:

2-bromo-1-(3-chloro-2-fluorophenyl)ethan-1-one → 2-[6-(3-chloro-2-fluorophenyl)-4-oxo-2-{[3-(1-piperidinyl)propyl]oxy}pyrazolo[1,5-a]pyrazin-5(4H)-yl]-N-(1-methylethyl)acetamide hydrochloride salt (1192313-10-2)

Guidance literature:

Multi-step reaction with 5 steps

1.1: potassium carbonate / N,N-dimethyl-formamide / 0.25 h / 20 °C

1.2: 20 °C

2.1: ammonium acetate; acetic acid / Heating; Reflux

3.1: acetic acid / Heating; Reflux

4.1: acetic acid / Heating; Reflux

5.1: potassium carbonate / N,N-dimethyl-formamide / 20 - 60 °C

5.2: 0.5 h / 0 °C

With ammonium acetate; potassium carbonate; acetic acid; In N,N-dimethyl-formamide;

Reference yield:

C20H24ClFN4O3 → 2-[6-(3-chloro-2-fluorophenyl)-4-oxo-2-{[3-(1-piperidinyl)propyl]oxy}pyrazolo[1,5-a]pyrazin-5(4H)-yl]-N-(1-methylethyl)acetamide hydrochloride salt (1192313-10-2)

Guidance literature:

Multi-step reaction with 3 steps

1.1: acetic acid / Heating; Reflux

2.1: acetic acid / Heating; Reflux

3.1: potassium carbonate / N,N-dimethyl-formamide / 20 - 60 °C

3.2: 0.5 h / 0 °C

With potassium carbonate; acetic acid; In N,N-dimethyl-formamide;

upstream raw materials:

2-chloro-N-isopropylacetamide

6-(3-chloro-2-fluoro-phenyl)-2-(3-piperidin-1-yl-propoxy)-5H-pyrazolo[1,5-a]pyrazin-4-one

1-(3-chloropropyl)piperidine hydrochloride

1-(3-chloro-2-fluorophenyl)ethan-1-one

Refernces