2-[3-(N,N-dimethylamino)-2-(4,5-dimethoxy-2-iodophenyl)acryloyl]-3,5-dimethoxyphenyl benzoate

Base Information

Chemical Name:2-[3-(N,N-dimethylamino)-2-(4,5-dimethoxy-2-iodophenyl)acryloyl]-3,5-dimethoxyphenyl benzoate
CAS No.:478316-41-5
Molecular Formula:C₂₈H₂₈INO₇
Molecular Weight:617.437
Hs Code.:

Synonyms:2-[3-(N,N-dimethylamino)-2-(4,5-dimethoxy-2-iodophenyl)acryloyl]-3,5-dimethoxyphenyl benzoate

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Chemical Property of 2-[3-(N,N-dimethylamino)-2-(4,5-dimethoxy-2-iodophenyl)acryloyl]-3,5-dimethoxyphenyl benzoate

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Technology Process of 2-[3-(N,N-dimethylamino)-2-(4,5-dimethoxy-2-iodophenyl)acryloyl]-3,5-dimethoxyphenyl benzoate

There total 5 articles about 2-[3-(N,N-dimethylamino)-2-(4,5-dimethoxy-2-iodophenyl)acryloyl]-3,5-dimethoxyphenyl benzoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 58.0%

: 4637-24-5
N,N-dimethyl-formamide dimethyl acetal

: 478316-36-8
2-[2-(4,5-dimethoxy-2-iodophenyl)acetyl]-3,5-dimethoxyphenyl benzoate

: 478316-41-5
2-[3-(N,N-dimethylamino)-2-(4,5-dimethoxy-2-iodophenyl)acryloyl]-3,5-dimethoxyphenyl benzoate

Guidance literature:: In toluene; at 90 ℃;
DOI:10.1021/jo025767j

Reference yield:

: 93-40-3
(3,4-Dimethoxyphenyl)acetic acid

: 478316-41-5
2-[3-(N,N-dimethylamino)-2-(4,5-dimethoxy-2-iodophenyl)acryloyl]-3,5-dimethoxyphenyl benzoate

Guidance literature:: Multi-step reaction with 5 steps

1: 92 percent / iodine monochloride / acetic acid / 1.5 h / 20 °C

2: SOCl₂ / toluene / 3.5 h / 135 °C

3: 65 percent / BF₃*OEt₂ / toluene / 7 h / 140 °C

4: 95 percent / NaOH; triethylbenzylammonium chloride / tetrahydrofuran / 4 h / 20 °C

5: 58 percent / toluene / 90 °C

With sodium hydroxide; thionyl chloride; boron trifluoride diethyl etherate; N-benzyl-N,N,N-triethylammonium chloride; Iodine monochloride; In tetrahydrofuran; acetic acid; toluene; 3: Friedel-Crafts acylation / 5: Vilsmeier-Haack reaction;
DOI:10.1021/jo025767j

Reference yield:

: 35323-09-2
(2-iodo-4,5-dimethoxyphenyl)acetic acid

: 478316-41-5
2-[3-(N,N-dimethylamino)-2-(4,5-dimethoxy-2-iodophenyl)acryloyl]-3,5-dimethoxyphenyl benzoate

Guidance literature:: Multi-step reaction with 4 steps

1: SOCl₂ / toluene / 3.5 h / 135 °C

2: 65 percent / BF₃*OEt₂ / toluene / 7 h / 140 °C

3: 95 percent / NaOH; triethylbenzylammonium chloride / tetrahydrofuran / 4 h / 20 °C

4: 58 percent / toluene / 90 °C

With sodium hydroxide; thionyl chloride; boron trifluoride diethyl etherate; N-benzyl-N,N,N-triethylammonium chloride; In tetrahydrofuran; toluene; 2: Friedel-Crafts acylation / 4: Vilsmeier-Haack reaction;
DOI:10.1021/jo025767j