2-[(2-fluoro-4-iodophenyl)amino]thieno[2,3-b]pyridine-3-carbonyl fluoride

Base Information

Chemical Name:2-[(2-fluoro-4-iodophenyl)amino]thieno[2,3-b]pyridine-3-carbonyl fluoride
CAS No.:1174730-72-3
Molecular Formula:C₁₄H₇F₂IN₂OS
Molecular Weight:416.19
Hs Code.:

Synonyms:2-[(2-fluoro-4-iodophenyl)amino]thieno[2,3-b]pyridine-3-carbonyl fluoride

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Chemical Property of 2-[(2-fluoro-4-iodophenyl)amino]thieno[2,3-b]pyridine-3-carbonyl fluoride

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Technology Process of 2-[(2-fluoro-4-iodophenyl)amino]thieno[2,3-b]pyridine-3-carbonyl fluoride

There total 4 articles about 2-[(2-fluoro-4-iodophenyl)amino]thieno[2,3-b]pyridine-3-carbonyl fluoride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 61.0%

: 945530-36-9
2-((2-fluoro-4-iodophenyl)amino)thieno[2,3-b]pyridine-3-carboxylic acid

: 1174730-72-3
2-[(2-fluoro-4-iodophenyl)amino]thieno[2,3-b]pyridine-3-carbonyl fluoride

Guidance literature:: With diethylamino-sulfur trifluoride; In dichloromethane; at 20 ℃; for 3h;

Reference yield:

: 101012-32-2
2-(2-chloropyridin-3-yl)acetonitrile

: 1174730-72-3
2-[(2-fluoro-4-iodophenyl)amino]thieno[2,3-b]pyridine-3-carbonyl fluoride

Guidance literature:: Multi-step reaction with 3 steps

1.1: sodium hydroxide / 0.5 h / Reflux

1.2: 0 - 10 °C / pH 1

2.1: lithium diisopropyl amide / tetrahydrofuran; hexanes / 0 °C

2.2: 0 - 65 °C

2.3: 0 °C

3.1: diethylamino-sulfur trifluoride / dichloromethane / 3 h / 20 °C

With diethylamino-sulfur trifluoride; sodium hydroxide; lithium diisopropyl amide; In tetrahydrofuran; hexanes; dichloromethane;

Reference yield:

: 89581-84-0
2-chloro-3-(chloromethyl)pyridine

: 1174730-72-3
2-[(2-fluoro-4-iodophenyl)amino]thieno[2,3-b]pyridine-3-carbonyl fluoride

Guidance literature:: Multi-step reaction with 4 steps

1.1: ethanol; water / 3 h / Inert atmosphere; Reflux

2.1: sodium hydroxide / 0.5 h / Reflux

2.2: 0 - 10 °C / pH 1

3.1: lithium diisopropyl amide / tetrahydrofuran; hexanes / 0 °C

3.2: 0 - 65 °C

3.3: 0 °C

4.1: diethylamino-sulfur trifluoride / dichloromethane / 3 h / 20 °C

With diethylamino-sulfur trifluoride; sodium hydroxide; lithium diisopropyl amide; In tetrahydrofuran; hexanes; ethanol; dichloromethane; water;