89581-84-0

Basic information

• Product Name: 2-BROMO-3-(CHLOROMETHYL)PYRIDINE
• Synonyms: 2-BROMO-3-(CHLOROMETHYL)PYRIDINE;2-Chloro-3-(chloroMethyl)...;Pyridine, 2-chloro-3-(chloroMethyl)-
• CAS NO: 89581-84-0
• Molecular Formula: C₆H₅Cl₂N
• Molecular Weight: 162.02
• EINECS: 145-896-5
• Mol File: 89581-84-0.mol
• Article Data: 13

Chemical Properties

• Boiling Point: 250℃
• Flash Point: 129℃
• Appearance: /
• Density: 1.324
• Vapor Pressure: 0.007mmHg at 25°C
• Refractive Index: 1.575
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C
• PKA: -0.18±0.10(Predicted)
• CAS DataBase Reference: 2-BROMO-3-(CHLOROMETHYL)PYRIDINE(CAS DataBase Reference)
• NIST Chemistry Reference: 2-BROMO-3-(CHLOROMETHYL)PYRIDINE(89581-84-0)
• EPA Substance Registry System: 2-BROMO-3-(CHLOROMETHYL)PYRIDINE(89581-84-0)

Safety Data

• Hazardous Substances Data: 89581-84-0(Hazardous Substances Data)

Usage

Description

2-BROMO-3-(CHLOROMETHYL)PYRIDINE, with the molecular formula C6H5BrClN, is a pyridine derivative featuring a bromine atom and a chloromethyl group attached to the second and third positions, respectively. This chemical compound serves as a versatile intermediate in the synthesis of various pharmaceuticals and agrochemicals, and is recognized for its antimicrobial properties. It is also utilized as a building block in organic synthesis for creating complex molecules with biological activity. Due to its toxic nature and potential hazards to human health, careful handling is essential.

Uses

Used in Pharmaceutical Industry:
2-BROMO-3-(CHLOROMETHYL)PYRIDINE is used as a chemical intermediate for the synthesis of various pharmaceutical drugs. Its unique structure allows for the development of new compounds with therapeutic properties, contributing to the advancement of medicinal chemistry.
Used in Agrochemical Industry:
In the agrochemical sector, 2-BROMO-3-(CHLOROMETHYL)PYRIDINE is employed as an intermediate in the production of pesticides and other agrochemicals. Its antimicrobial properties make it a valuable component in creating effective solutions for crop protection and disease control.
Used in Veterinary Medicine:
2-BROMO-3-(CHLOROMETHYL)PYRIDINE is utilized in the veterinary field for the synthesis of veterinary products. Its antimicrobial characteristics aid in the development of medications and treatments for various animal health issues.
Used in Organic Synthesis:
As a building block in organic synthesis, 2-BROMO-3-(CHLOROMETHYL)PYRIDINE is used for the creation of complex molecules with biological activity. Its unique structure allows for the formation of diverse compounds with potential applications in various industries, including pharmaceuticals, agrochemicals, and materials science.

InChI:InChI=1/C6H5BrClN/c7-6-5(4-8)2-1-3-9-6/h1-3H,4H2

Upstream product

• 18368-76-8 2 chloro-3-methylpyridine 
• 2942-59-8 2-chloronicotinic acid 
• 49609-84-9 2-Chloronicotinoyl chloride 
• 59-67-6 nicotinic acid 
• 36404-88-3 2-chloro-3-carbaldehydepyridine 
• 42330-59-6 (2-chloropyrid-3-yl)methanol 

Downstream Products

• 101012-32-2 2-(2-chloropyridin-3-yl)acetonitrile 
• 1357305-91-9 3-(2-chloropyrid-3-ylmethoxy)-1-benzhydrylazetidine 
• 884049-52-9 spiro[piperidine-4,3'-pyrrolo[2,3-b]pyridin]-2'(1'H)-one 
• 885031-86-7 tert-butyl 2'-oxo-1',2'-dihydro-1H-spiro[piperidine-4,3'-pyrrolo[2.3-b]pyridine]-1-carboxylate 
• 61494-55-1 2-Chloro-pyridin-3-yl acetic acid 
• 36404-88-3 2-chloro-3-carbaldehydepyridine 
• 2942-59-8 2-chloronicotinic acid 
• 845552-76-3 1-benzyl-1',2'-dihydrospiro[piperidine-4,3'-pyrrolo[2,3-b]-pyridine] 
• 845552-77-4 1-benzyl-4-(2-chloropyridin-3-yl)piperidine-4-carbonitrile 
• 1360552-63-1 C₂₂H₂₁ClN₆O 
• 1101170-92-6 tert-butyl {4'-chloro-6-[(2-chloropyridine-3-carbonyl)amino]biphen-3-yl}carbamate 
• 422550-95-6 3-[({2-[3-benzyl-5-(1,1-dioxo-isothiazolidin-2-ylmethyl)-phenyl]-2-oxo-ethyl}-benzyloxycarbonyl-amino)-methyl]-pyridine-2-carboxylic acid ethyl ester 
• 1026627-33-7 {2-[3-benzyl-5-(1,1-dioxo-isothiazolidin-2-ylmethyl)-phenyl]-2-oxo-ethyl}-(2-chloro-pyridin-3-ylmethyl)-carbamic acid benzyl ester 
• 422550-94-5 1-[3-benzyl-5-(1,1-dioxoisothiazolidin-2-ylmethyl)-phenyl]-1-(8-hydroxy-[1,6]naphthyridin-7-yl)-methanone 

Relevant articles and documents

Structure-guided optimization of 1H-imidazole-2-carboxylic acid derivatives affording potent VIM-Type metallo-β-lactamase inhibitors

Production of metallo-β-lactamases (MBLs) in bacterial pathogens is an important cause of resistance to the ‘last-resort’ carbapenem antibiotics. Development of effective MBL inhibitors to reverse carbapenem resistance in Gram-negative bacteria is still needed. We herein report X-ray structure-guided optimization of 1H-imidazole-2-carboxylic acid (ICA) derivatives by considering how to engage with the active-site flexible loops and improve penetration into Gram-negative bacteria. Structure-activity relationship studies revealed the importance of appropriate substituents at ICA 1-position to achieve potent inhibition to class B1 MBLs, particularly the Verona Integron-encoded MBLs (VIMs), mainly by involving ingenious interactions with the flexible active site loops as observed by crystallographic analyses. Of the tested ICA inhibitors, 55 displayed potent synergistic antibacterial activity with meropenem against engineered Escherichia coli strains and even intractable clinically isolated Pseudomonas aeruginosa producing VIM-2 MBL. The morphologic and internal structural changes of bacterial cells after treatment further demonstrated that 55 crossed the outer membrane and reversed the activity of meropenem. Moreover, 55 showed good pharmacokinetic and safety profile in vivo, which could be a potential candidate for combating VIM-mediated Gram-negative carbapenem resistance.

DIFLUOROMETHYLENE COMPOUND

The present invention relates to a compound having an URAT1 inhibitory activity, and to an URAT1 inhibitor, a blood uric acid level-reducing agent and a pharmaceutical composition containing the compound. More specifically, the present invention relates to a compound represented by the formula (I): wherein R1 is -Q1-A1 or the like; R2 is a hydrogen atom, a halogen atom, a lower alkyl group or the like; W1, W2, W3 and W4 are each independently a nitrogen atom or a methine group optionally having substituents, or the like; X and Y are each a single bond, an oxygen atom or the like; Z is a hydroxyl group or COOR3 or the like.

Fatty acid amide hydrolase inhibitors. 3: Tetra-substituted azetidine ureas with in vivo activity

We describe here our attempts to optimise the human fatty acid amide hydrolase (FAAH) inhibition and physicochemical properties of our previously reported tetrasubstituted azetidine urea FAAH inhibitor, VER-156084. We describe the SAR of a series of analogues and conclude with the demonstration of in vivo dose-dependant FAAH inhibition in an anandamide-loading study in rats.