7-syn-<(benzyloxy)methyl>-2-(ethoxycarbonyl)-2-azabicyclo<2.2.1>hept-5-en-3-one

Base Information

Chemical Name:7-syn-<(benzyloxy)methyl>-2-(ethoxycarbonyl)-2-azabicyclo<2.2.1>hept-5-en-3-one
CAS No.:140440-33-1
Molecular Formula:C₁₇H₁₉NO₄
Molecular Weight:301.342
Hs Code.:

Synonyms:7-syn-<(benzyloxy)methyl>-2-(ethoxycarbonyl)-2-azabicyclo<2.2.1>hept-5-en-3-one

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 7-syn-<(benzyloxy)methyl>-2-(ethoxycarbonyl)-2-azabicyclo<2.2.1>hept-5-en-3-one

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Technology Process of 7-syn-<(benzyloxy)methyl>-2-(ethoxycarbonyl)-2-azabicyclo<2.2.1>hept-5-en-3-one

There total 1 articles about 7-syn-<(benzyloxy)methyl>-2-(ethoxycarbonyl)-2-azabicyclo<2.2.1>hept-5-en-3-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 541-41-3
chloroformic acid ethyl ester

: 140440-30-8
7-syn-<(benzyloxy)methyl>-2-azabicyclo<2.2.1>hept-5-en-3-one

: 140440-33-1
7-syn-<(benzyloxy)methyl>-2-(ethoxycarbonyl)-2-azabicyclo<2.2.1>hept-5-en-3-one

Guidance literature:: With lithium diisopropyl amide; Yield given. Multistep reaction; 1.) THF, hexane, -78 deg C, 1 h, 2.) THF, hexane, RT, 12 h;
DOI:10.1021/jm00088a026

Reference yield: 83.0%

: 140440-33-1
7-syn-<(benzyloxy)methyl>-2-(ethoxycarbonyl)-2-azabicyclo<2.2.1>hept-5-en-3-one

: 140440-34-2
ethyl (+/-)-N-<5α-<(benzyloxy)methyl>-4β-(hydroxymethyl)cyclopent-2-en-1β-yl>carbamate

Guidance literature:: With sodium tetrahydroborate; In methanol; for 1h; Ambient temperature;
DOI:10.1021/jm00088a026

Reference yield:

: 140440-33-1
7-syn-<(benzyloxy)methyl>-2-(ethoxycarbonyl)-2-azabicyclo<2.2.1>hept-5-en-3-one

: 140440-39-7
[(1S,4R,5R)-5-Benzyloxymethyl-4-(6-methoxy-purin-9-yl)-cyclopent-2-enyl]-methanol

Guidance literature:: Multi-step reaction with 5 steps

1: 83 percent / NaBH₄ / methanol / 1 h / Ambient temperature

2: 86 percent / aq. KOH / methanol / 20 h / Heating

3: 82 percent / triethylamine / ethanol / 48 h / 100 °C

4: 86 percent / 12N aq. HCl / 12 h / Ambient temperature

5: 9 percent / NH₃ / 20 h / 50 °C

With hydrogenchloride; potassium hydroxide; sodium tetrahydroborate; ammonia; triethylamine; In methanol; ethanol;
DOI:10.1021/jm00088a026