2-((([5-amino-1-(4-fluorophenyl)-1H-pyrazol-4-yl]carbonyl)amino)methyl)-3,3,3-trifluoro-2-hydroxypropyl 4-methylbenzenesulfonate

Base Information

Chemical Name:2-((([5-amino-1-(4-fluorophenyl)-1H-pyrazol-4-yl]carbonyl)amino)methyl)-3,3,3-trifluoro-2-hydroxypropyl 4-methylbenzenesulfonate
CAS No.:960249-74-5
Molecular Formula:C₂₁H₂₀F₄N₄O₅S
Molecular Weight:516.473
Hs Code.:

Synonyms:2-((([5-amino-1-(4-fluorophenyl)-1H-pyrazol-4-yl]carbonyl)amino)methyl)-3,3,3-trifluoro-2-hydroxypropyl 4-methylbenzenesulfonate

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Chemical Property of 2-((([5-amino-1-(4-fluorophenyl)-1H-pyrazol-4-yl]carbonyl)amino)methyl)-3,3,3-trifluoro-2-hydroxypropyl 4-methylbenzenesulfonate

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Technology Process of 2-((([5-amino-1-(4-fluorophenyl)-1H-pyrazol-4-yl]carbonyl)amino)methyl)-3,3,3-trifluoro-2-hydroxypropyl 4-methylbenzenesulfonate

There total 1 articles about 2-((([5-amino-1-(4-fluorophenyl)-1H-pyrazol-4-yl]carbonyl)amino)methyl)-3,3,3-trifluoro-2-hydroxypropyl 4-methylbenzenesulfonate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 79.0%

: 960249-73-4
5-amino-1-(4-fluorophenyl)-N-(3,3,3-trifluoro-2-hydroxy-2-(hydroxymethyl)propyl)-1H-pyrazole-4-carboxamide

: 98-59-9
p-toluenesulfonyl chloride

: 960249-74-5
2-((([5-amino-1-(4-fluorophenyl)-1H-pyrazol-4-yl]carbonyl)amino)methyl)-3,3,3-trifluoro-2-hydroxypropyl 4-methylbenzenesulfonate

Guidance literature:: With pyridine; In dichloromethane; at 0 - 20 ℃;

Reference yield:

: 960249-74-5
2-((([5-amino-1-(4-fluorophenyl)-1H-pyrazol-4-yl]carbonyl)amino)methyl)-3,3,3-trifluoro-2-hydroxypropyl 4-methylbenzenesulfonate

: 960249-75-6
5-amino-1-(4-fluorophenyl)-N-((2-(trifluoromethyl)-2-oxiranyl)methyl)-1H-pyrazole-4-carboxamide

Guidance literature:: With polymer-supported carbonate resin; In tetrahydrofuran; for 15h;

Reference yield:

: 960249-74-5
2-((([5-amino-1-(4-fluorophenyl)-1H-pyrazol-4-yl]carbonyl)amino)methyl)-3,3,3-trifluoro-2-hydroxypropyl 4-methylbenzenesulfonate

: 5-amino-N-[2-({[(2,6-dichlorophenyl)carbonyl]amino}methyl)-3,3,3-trifluoro-2-hydroxypropyl]-1-(4-fluorophenyl)-1H-pyrazole-4-carboxamide

Guidance literature:: Multi-step reaction with 4 steps

1: polymer supported carbonate resin / tetrahydrofuran / 15 h

2: 1,4-dioxane / 20 h / 20 °C

3: hydrogen / palladium 10% on activated carbon / ethanol

4: N-ethyl-N,N-diisopropylamine / tetrahydrofuran / 17.33 h / 0 - 21 °C

With hydrogen; N-ethyl-N,N-diisopropylamine; palladium 10% on activated carbon; In tetrahydrofuran; 1,4-dioxane; ethanol;