3-[[(4,5-dihydro-5,5-dimethyl-3-isoxazolyl)thio]methyl]-2-(phenylmethoxy)-4-(trifluoromethyl)pyridine

Base Information

Chemical Name:3-[[(4,5-dihydro-5,5-dimethyl-3-isoxazolyl)thio]methyl]-2-(phenylmethoxy)-4-(trifluoromethyl)pyridine
CAS No.:1202473-96-8
Molecular Formula:C₁₉H₁₉F₃N₂O₂S
Molecular Weight:396.433
Hs Code.:

Synonyms:3-[[(4,5-dihydro-5,5-dimethyl-3-isoxazolyl)thio]methyl]-2-(phenylmethoxy)-4-(trifluoromethyl)pyridine

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Chemical Property of 3-[[(4,5-dihydro-5,5-dimethyl-3-isoxazolyl)thio]methyl]-2-(phenylmethoxy)-4-(trifluoromethyl)pyridine

Chemical Property:

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Technology Process of 3-[[(4,5-dihydro-5,5-dimethyl-3-isoxazolyl)thio]methyl]-2-(phenylmethoxy)-4-(trifluoromethyl)pyridine

There total 6 articles about 3-[[(4,5-dihydro-5,5-dimethyl-3-isoxazolyl)thio]methyl]-2-(phenylmethoxy)-4-(trifluoromethyl)pyridine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: [5,5-dimethyl(4,5-dihydroisoxazol-3-yl)]thiocarboxamidine hydrochloride

: 1202473-95-7
3-(bromomethyl)-2-(phenylmethoxy)-4-(trifluoromethyl)pyridine

: 1202473-96-8
3-[[(4,5-dihydro-5,5-dimethyl-3-isoxazolyl)thio]methyl]-2-(phenylmethoxy)-4-(trifluoromethyl)pyridine

Guidance literature:: With potassium carbonate; In acetonitrile; at 20 ℃; for 18h;

Reference yield:

: 1202473-93-5
phenylmethyl 2-(phenylmethoxy)-4-(trifluoromethyl)-3-pyridinecarboxylate

: 1202473-96-8
3-[[(4,5-dihydro-5,5-dimethyl-3-isoxazolyl)thio]methyl]-2-(phenylmethoxy)-4-(trifluoromethyl)pyridine

Guidance literature:: Multi-step reaction with 3 steps

1: diisobutylaluminium hydride / dichloromethane; toluene / -78 - 0 °C

2: carbon tetrabromide; triphenylphosphine / dichloromethane / 1.5 h / 20 °C

3: potassium carbonate / acetonitrile / 18 h / 20 °C

With carbon tetrabromide; diisobutylaluminium hydride; potassium carbonate; triphenylphosphine; In dichloromethane; toluene; acetonitrile;

Reference yield:

: 1202473-92-4
phenylmethyl 2-chloro-4-(trifluoromethyl)-3-pyridinecarboxylate

: 1202473-96-8
3-[[(4,5-dihydro-5,5-dimethyl-3-isoxazolyl)thio]methyl]-2-(phenylmethoxy)-4-(trifluoromethyl)pyridine

Guidance literature:: Multi-step reaction with 4 steps

1.1: sodium hydride / 1-methyl-pyrrolidin-2-one; mineral oil / 0.17 h / 20 °C

1.2: 20 °C / Cooling with ice-water

2.1: diisobutylaluminium hydride / dichloromethane; toluene / -78 - 0 °C

3.1: carbon tetrabromide; triphenylphosphine / dichloromethane / 1.5 h / 20 °C

4.1: potassium carbonate / acetonitrile / 18 h / 20 °C

With carbon tetrabromide; sodium hydride; diisobutylaluminium hydride; potassium carbonate; triphenylphosphine; In 1-methyl-pyrrolidin-2-one; dichloromethane; toluene; acetonitrile; mineral oil;