phenylmethyl 2-(phenylmethoxy)-4-(trifluoromethyl)-3-pyridinecarboxylate

Base Information

Chemical Name:phenylmethyl 2-(phenylmethoxy)-4-(trifluoromethyl)-3-pyridinecarboxylate
CAS No.:1202473-93-5
Molecular Formula:C₂₁H₁₆F₃NO₃
Molecular Weight:387.358
Hs Code.:

Synonyms:phenylmethyl 2-(phenylmethoxy)-4-(trifluoromethyl)-3-pyridinecarboxylate

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Chemical Property of phenylmethyl 2-(phenylmethoxy)-4-(trifluoromethyl)-3-pyridinecarboxylate

Chemical Property:

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Technology Process of phenylmethyl 2-(phenylmethoxy)-4-(trifluoromethyl)-3-pyridinecarboxylate

There total 2 articles about phenylmethyl 2-(phenylmethoxy)-4-(trifluoromethyl)-3-pyridinecarboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1202473-92-4
phenylmethyl 2-chloro-4-(trifluoromethyl)-3-pyridinecarboxylate

: 100-51-6,185532-71-2
benzyl alcohol

: 1202473-93-5
phenylmethyl 2-(phenylmethoxy)-4-(trifluoromethyl)-3-pyridinecarboxylate

Guidance literature:: benzyl alcohol; With sodium hydride; In 1-methyl-pyrrolidin-2-one; mineral oil; at 20 ℃; for 0.166667h;

phenylmethyl 2-chloro-4-(trifluoromethyl)-3-pyridinecarboxylate; In 1-methyl-pyrrolidin-2-one; mineral oil; at 20 ℃; Cooling with ice-water;

Reference yield:

: 81565-18-6
2-chloro-4-trifluoromethyl pyridine

: 501-53-1,94274-21-2
benzyl chloroformate

: 1202473-93-5
phenylmethyl 2-(phenylmethoxy)-4-(trifluoromethyl)-3-pyridinecarboxylate

Guidance literature:: Multi-step reaction with 2 steps

1.1: n-butyllithium; diisopropylamine / tetrahydrofuran; hexanes / -78 - -70 °C

1.2: -68 °C

2.1: sodium hydride / 1-methyl-pyrrolidin-2-one; mineral oil / 0.17 h / 20 °C

2.2: 20 °C / Cooling with ice-water

With n-butyllithium; sodium hydride; diisopropylamine; In tetrahydrofuran; 1-methyl-pyrrolidin-2-one; hexanes; mineral oil;

Reference yield:

: 1202473-93-5
phenylmethyl 2-(phenylmethoxy)-4-(trifluoromethyl)-3-pyridinecarboxylate

: 1202473-94-6
2-(phenylmethoxy)-4-(trifluoromethyl)-3-pyridinemethanol

Guidance literature:: phenylmethyl 2-(phenylmethoxy)-4-(trifluoromethyl)-3-pyridinecarboxylate; With diisobutylaluminium hydride; In dichloromethane; toluene; at -78 - 0 ℃;

With water; Rochelle's salt; In dichloromethane; ethyl acetate; toluene;