1-(4-chlorophenyl)-2-(2-hydroxyphenyl)-4-phenylpyrrole-3-carboxylic acid

Base Information

• Chemical Name: 1-(4-chlorophenyl)-2-(2-hydroxyphenyl)-4-phenylpyrrole-3-carboxylic acid
• CAS No.: 127792-08-9
• Molecular Formula: C₂₃H₁₆ClNO₃
• Molecular Weight: 389.838
• Mol file: 127792-08-9.mol

Synonyms:1-(4-chlorophenyl)-2-(2-hydroxyphenyl)-4-phenylpyrrole-3-carboxylic acid

Chemical Property of 1-(4-chlorophenyl)-2-(2-hydroxyphenyl)-4-phenylpyrrole-3-carboxylic acid

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

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Technology Process of 1-(4-chlorophenyl)-2-(2-hydroxyphenyl)-4-phenylpyrrole-3-carboxylic acid

There total 4 articles about 1-(4-chlorophenyl)-2-(2-hydroxyphenyl)-4-phenylpyrrole-3-carboxylic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 70.0%

1-(4-chlorophenyl)-2-<2-(benzyloxy)phenyl>-4-phenylpyrrole-3-carboxylic acid (127792-01-2) → 1-(4-chlorophenyl)-2-(2-hydroxyphenyl)-4-phenylpyrrole-3-carboxylic acid (127792-08-9)

Guidance literature:

With hydrogen; palladium on activated charcoal; In ethyl acetate; under 2068.6 Torr;

DOI:10.1021/jm00171a047

Reference yield:

ethyl 3-<2-(benzyloxy)phenyl>-3-oxopropanoate (39208-08-7) → 1-(4-chlorophenyl)-2-(2-hydroxyphenyl)-4-phenylpyrrole-3-carboxylic acid (127792-08-9)

Guidance literature:

Multi-step reaction with 3 steps

1: 65 percent / 4-chloroaniline hydrobromide, zink chloride / benzene / Heating

2: 30 percent / sodium hydroxide / ethanol / 48 h / Heating

3: 70 percent / H₂ / 10percent Pd/C / ethyl acetate / 2068.6 Torr

With sodium hydroxide; hydrogen; p-chlorobenzenamine hydrobromide; zinc(II) chloride; palladium on activated charcoal; In ethanol; ethyl acetate; benzene;

DOI:10.1021/jm00171a047

Reference yield:

2-[(4-chlorophenyl)amino]-1-phenylethanone (53181-22-9) → 1-(4-chlorophenyl)-2-(2-hydroxyphenyl)-4-phenylpyrrole-3-carboxylic acid (127792-08-9)

Guidance literature:

Multi-step reaction with 3 steps

1: 65 percent / 4-chloroaniline hydrobromide, zink chloride / benzene / Heating

2: 30 percent / sodium hydroxide / ethanol / 48 h / Heating

3: 70 percent / H₂ / 10percent Pd/C / ethyl acetate / 2068.6 Torr

With sodium hydroxide; hydrogen; p-chlorobenzenamine hydrobromide; zinc(II) chloride; palladium on activated charcoal; In ethanol; ethyl acetate; benzene;

DOI:10.1021/jm00171a047

upstream raw materials:

1-(4-chlorophenyl)-2-<2-(benzyloxy)phenyl>-4-phenylpyrrole-3-carboxylic acid

ethyl 3-<2-(benzyloxy)phenyl>-3-oxopropanoate

2-[(4-chlorophenyl)amino]-1-phenylethanone

ethyl 1-(4-chlorophenyl)-2-<2-(benzyloxy)phenyl>-4-phenylpyrrole-3-carboxylate

Downstream raw materials:

1,4-dihydro-1-(4-chlorophenyl)-3-phenyl<1>benzopyrano<4,3-b>pyrrol-4-one