53181-22-9

Basic information

• Product Name: 2-(4-CHLOROANILINO)-1-PHENYL-1-ETHANONE
• Synonyms: 2-(4-CHLOROANILINO)-1-PHENYL-1-ETHANONE;2-(4-Chloroanilino)-1-phenylethan-1-one
• CAS NO: 53181-22-9
• Molecular Formula: C₁₄H₁₂ClNO
• Molecular Weight: 245.70418
• Mol File: 53181-22-9.mol
• Article Data: 19

Chemical Properties

• Melting Point: 164-166
• Boiling Point: 429.29 °C at 760 mmHg
• Flash Point: 213.427 °C
• Appearance: /
• Density: 1.249g/cm³
• Vapor Pressure: 0mmHg at 25°C
• Refractive Index: 1.634
• CAS DataBase Reference: 2-(4-CHLOROANILINO)-1-PHENYL-1-ETHANONE(CAS DataBase Reference)
• NIST Chemistry Reference: 2-(4-CHLOROANILINO)-1-PHENYL-1-ETHANONE(53181-22-9)
• EPA Substance Registry System: 2-(4-CHLOROANILINO)-1-PHENYL-1-ETHANONE(53181-22-9)

Safety Data

• Hazard Codes: Xi
• HazardClass: IRRITANT
• Hazardous Substances Data: 53181-22-9(Hazardous Substances Data)

Usage

General Description

2-(4-chloroanilino)-1-phenyl-1-ethanone is a chemical compound with the molecular formula C15H13ClNO. It is an organic compound that belongs to the class of phenylketones and contains a chloroaniline group. 2-(4-CHLOROANILINO)-1-PHENYL-1-ETHANONE is commonly used in pharmaceutical research and can act as an intermediate in the synthesis of various biologically active compounds. Its structure and properties make it suitable for use in the development of pharmacological agents and as a building block in the synthesis of complex organic molecules. However, due to its potentially hazardous nature, it should be handled and used with caution in accordance with safety guidelines and regulations.

InChI:InChI=1/C14H12ClNO/c15-12-6-8-13(9-7-12)16-10-14(17)11-4-2-1-3-5-11/h1-9,16H,10H2

Upstream product

• 1074-12-0 phenylglyoxal hydrate 
• 106-47-8 4-chloro-aniline 
• 100-58-3 phenylmagnesium bromide 
• 98-86-2 acetophenone 
• 112537-84-5 phenacyl m-nitrobenzenesulphonate 
• 110143-20-9 α-(p-chlorobenzenesulfonyloxy)acetophenone 
• 98475-06-0 α-phenylsulfonyloxyacetophenone 
• 7257-94-5 1-phenyl-2-(p-tolylsulfonyloxy)ethanone 
• 70-11-1 α-bromoacetophenone 

Downstream Products

• 1374667-46-5 N,N'-bis(4-chlorophenyl)-2-oxo-2-phenylacetimidamide 
• 948-65-2 2-phenyl-indole 
• 23746-76-1 5-chloro-2-phenylindole 
• 1213786-12-9 5‐chloro‐2‐phenyl‐3‐(phenylthio)‐1H‐indole 
• 58268-09-0 2-[(4-chlorophenyl)amino]-1,2-diphenylethan-1-one 

Relevant articles and documents

Phosphine-Catalyzed Synthesis of Chiral N-Heterocycles through (Asymmetric) P(III)/P(V) Redox Cycling

Phosphine-catalyzed tandem Michael addition/intramolecular Wittig reactions have been developed for the synthesis of chiral 2,5-dihydro-1H-pyrrole and tetrahydropyridine derivatives. These processes have been rendered catalytic in phosphine, thanks to the in situ reduction of phosphine oxide by phenylsilane. Furthermore, catalytic and asymmetric P(III)/P(V) processes were implemented using enantiopure chiral phosphines.

Iodine monobromide catalysed regioselective synthesis of 3-arylquinolines from α-aminoacetophenones and: Trans -β-nitrostyrenes

A simple and efficient method for regioselective synthesis of 3-arylquinolines is described from α-aminoacetophenones and trans-β-nitrostyrenes using 20 mol% iodine monobromide as a catalyst in acetonitrile solvent at 80 °C. The present method involves tandem reaction of α-aminoacetophenones and trans-β-nitrostyrenes, formation of two new C-C bonds and cleavage of one C-C bond in a single step. The salient features of the protocol are metal- and oxidant-free reaction conditions, broad substrate scope, and good yields.

CERAMIDE GALACTOSYLTRANSFERASE INHIBITORS FOR THE TREATMENT OF DISEASE

Described herein are compounds, methods of making such compounds, pharmaceutical compositions and medicaments containing such compounds, and methods of using such compounds to treat or prevent diseases or disorders associated with the enzyme ceramide galactosyltransferase (CGT), such as, for example, lysosomal storage diseases. Examples of lysosomal storage diseases include, for example, Krabbe disease and Metachromatic Leukodystrophy.