1-(4-(6-(N-(2-(piperidin-1-yl)ethyl)aminocarbonyl)-1H-indazol-4-yl)phenyl)-3-(3-(trifluoromethoxy)phenyl)urea

Base Information

Chemical Name:1-(4-(6-(N-(2-(piperidin-1-yl)ethyl)aminocarbonyl)-1H-indazol-4-yl)phenyl)-3-(3-(trifluoromethoxy)phenyl)urea
CAS No.:1285531-68-1
Molecular Formula:C₂₉H₂₉F₃N₆O₃
Molecular Weight:566.583
Hs Code.:

Synonyms:1-(4-(6-(N-(2-(piperidin-1-yl)ethyl)aminocarbonyl)-1H-indazol-4-yl)phenyl)-3-(3-(trifluoromethoxy)phenyl)urea

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Chemical Property of 1-(4-(6-(N-(2-(piperidin-1-yl)ethyl)aminocarbonyl)-1H-indazol-4-yl)phenyl)-3-(3-(trifluoromethoxy)phenyl)urea

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Technology Process of 1-(4-(6-(N-(2-(piperidin-1-yl)ethyl)aminocarbonyl)-1H-indazol-4-yl)phenyl)-3-(3-(trifluoromethoxy)phenyl)urea

There total 6 articles about 1-(4-(6-(N-(2-(piperidin-1-yl)ethyl)aminocarbonyl)-1H-indazol-4-yl)phenyl)-3-(3-(trifluoromethoxy)phenyl)urea which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 80.0%

: 553661-25-9
phenyl N-[3-(trifluoromethoxy)phenyl]carbamate

: 1285532-20-8
C₂₁H₂₅N₅O

: 1285531-68-1
1-(4-(6-(N-(2-(piperidin-1-yl)ethyl)aminocarbonyl)-1H-indazol-4-yl)phenyl)-3-(3-(trifluoromethoxy)phenyl)urea

Guidance literature:: at 25 ℃; for 1h;

Reference yield:

: 885518-47-8
methyl 4-bromo-1H-indazole-6-carboxylate

: 1285531-68-1
1-(4-(6-(N-(2-(piperidin-1-yl)ethyl)aminocarbonyl)-1H-indazol-4-yl)phenyl)-3-(3-(trifluoromethoxy)phenyl)urea

Guidance literature:: Multi-step reaction with 4 steps

1.1: water; lithium hydroxide / ethanol / 20 h / 20 °C

1.2: pH 4

2.1: N-ethyl-N,N-diisopropylamine; 1,1'-carbonyldiimidazole / N,N-dimethyl-formamide / 2 h / 20 °C

3.1: sodium carbonate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / 1,2-dimethoxyethane; water / 16 h / 95 °C / Inert atmosphere

4.1: 1 h / 25 °C

With water; sodium carbonate; N-ethyl-N,N-diisopropylamine; 1,1'-carbonyldiimidazole; lithium hydroxide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In 1,2-dimethoxyethane; ethanol; water; N,N-dimethyl-formamide;

Reference yield:

: 96-98-0
4-methyl-3-nitrobenzoic acid

: 1285531-68-1
1-(4-(6-(N-(2-(piperidin-1-yl)ethyl)aminocarbonyl)-1H-indazol-4-yl)phenyl)-3-(3-(trifluoromethoxy)phenyl)urea

Guidance literature:: Multi-step reaction with 7 steps

1.1: DBDMH / sulfuric acid / 16 h / 20 °C

2.1: thionyl chloride / -5 °C / Reflux

3.1: acetic acid; iron / tetrahydrofuran / 10 h / Reflux

3.2: 10 h / Reflux

4.1: water; lithium hydroxide / ethanol / 20 h / 20 °C

4.2: pH 4

5.1: N-ethyl-N,N-diisopropylamine; 1,1'-carbonyldiimidazole / N,N-dimethyl-formamide / 2 h / 20 °C

6.1: sodium carbonate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / 1,2-dimethoxyethane; water / 16 h / 95 °C / Inert atmosphere

7.1: 1 h / 25 °C

With thionyl chloride; water; iron; sodium carbonate; acetic acid; N-ethyl-N,N-diisopropylamine; 1,1'-carbonyldiimidazole; lithium hydroxide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In tetrahydrofuran; 1,2-dimethoxyethane; ethanol; sulfuric acid; water; N,N-dimethyl-formamide;