1-<(tert-Butyldimethylsilyl)oxy>-2,6-dimethoxy-4-<4-butyl>benzene

Base Information

Chemical Name:1-<(tert-Butyldimethylsilyl)oxy>-2,6-dimethoxy-4-<4-butyl>benzene
CAS No.:158555-91-0
Molecular Formula:C₂₈H₃₉NO₅Si
Molecular Weight:497.707
Hs Code.:

1-<(tert-Butyldimethylsilyl)oxy>-2,6-dimethoxy-4-<4-<N-(methoxycarbonyl)indol-3-yl>butyl>benzene

Synonyms:1-<(tert-Butyldimethylsilyl)oxy>-2,6-dimethoxy-4-<4-butyl>benzene

Suppliers and Price of 1-<(tert-Butyldimethylsilyl)oxy>-2,6-dimethoxy-4-<4-butyl>benzene

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 1-<(tert-Butyldimethylsilyl)oxy>-2,6-dimethoxy-4-<4-butyl>benzene

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Technology Process of 1-<(tert-Butyldimethylsilyl)oxy>-2,6-dimethoxy-4-<4-butyl>benzene

There total 6 articles about 1-<(tert-Butyldimethylsilyl)oxy>-2,6-dimethoxy-4-<4-butyl>benzene which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 57.0%

: 79-22-1
methyl chloroformate

: 158555-50-1
1-<(tert-Butyldimethylsilyl)oxy>-2,6-dimethoxy-4-<4-(indol-3-yl)butyl>benzene

: 158555-91-0
1-<(tert-Butyldimethylsilyl)oxy>-2,6-dimethoxy-4-<4-butyl>benzene

Guidance literature:: With tert.-butyl lithium; In tetrahydrofuran; pentane; 1.) -78 deg C, 5 min, 2.) 10 min;
DOI:10.1021/jo00100a039

Reference yield:

: 18162-48-6
tert-butyldimethylsilyl chloride

: 158555-91-0
1-<(tert-Butyldimethylsilyl)oxy>-2,6-dimethoxy-4-<4-butyl>benzene

Guidance literature:: Multi-step reaction with 5 steps

1: 84 percent / imidazole / CH₂Cl₂ / 3 h / Ambient temperature

2: 99 percent / NaBH₄ / methanol

3: 92 percent / TMSBr / tetrahydrofuran

4: 1.) t-BuLi, CuCN / 1.) pentane, THF, -78 deg C, 5 min; THF, 0 deg C, 5 min, 2.) THF, -78 deg C, 50 min

5: 57 percent / t-BuLi / tetrahydrofuran; pentane / 1.) -78 deg C, 5 min, 2.) 10 min

With 1H-imidazole; sodium tetrahydroborate; trimethylsilyl bromide; tert.-butyl lithium; In tetrahydrofuran; methanol; dichloromethane; pentane;
DOI:10.1021/jo00100a039

Reference yield:

: 106852-80-6
4-(t-butyldimethylsilyloxy)-3,5-dimethoxybenzaldehyde

: 158555-91-0
1-<(tert-Butyldimethylsilyl)oxy>-2,6-dimethoxy-4-<4-butyl>benzene

Guidance literature:: Multi-step reaction with 4 steps

1: 99 percent / NaBH₄ / methanol

2: 92 percent / TMSBr / tetrahydrofuran

3: 1.) t-BuLi, CuCN / 1.) pentane, THF, -78 deg C, 5 min; THF, 0 deg C, 5 min, 2.) THF, -78 deg C, 50 min

4: 57 percent / t-BuLi / tetrahydrofuran; pentane / 1.) -78 deg C, 5 min, 2.) 10 min

With sodium tetrahydroborate; trimethylsilyl bromide; tert.-butyl lithium; In tetrahydrofuran; methanol; pentane;
DOI:10.1021/jo00100a039