N-{5-[4-amino-1-(phenylsulfonyl)-1H-indazol-6-yl]-3-pyridinyl}methanesulfonamide

Base Information

Chemical Name:N-{5-[4-amino-1-(phenylsulfonyl)-1H-indazol-6-yl]-3-pyridinyl}methanesulfonamide
CAS No.:1198803-15-4
Molecular Formula:C₁₉H₁₇N₅O₄S₂
Molecular Weight:443.507
Hs Code.:

Synonyms:N-{5-[4-amino-1-(phenylsulfonyl)-1H-indazol-6-yl]-3-pyridinyl}methanesulfonamide

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Chemical Property of N-{5-[4-amino-1-(phenylsulfonyl)-1H-indazol-6-yl]-3-pyridinyl}methanesulfonamide

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Technology Process of N-{5-[4-amino-1-(phenylsulfonyl)-1H-indazol-6-yl]-3-pyridinyl}methanesulfonamide

There total 5 articles about N-{5-[4-amino-1-(phenylsulfonyl)-1H-indazol-6-yl]-3-pyridinyl}methanesulfonamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 41.0%

: 1083326-18-4
N-(5-bromopyridin-3-yl)methanesulfonamide

: 1198437-73-8
1-((4-phenyl)sulfonyl)-6-(trimethylstannyl)-1H-indazol-4-amine

: 1198803-15-4
N-{5-[4-amino-1-(phenylsulfonyl)-1H-indazol-6-yl]-3-pyridinyl}methanesulfonamide

Guidance literature:: With chloro(di-2-norbornylphosphino)(2'-dimethylamino-1,1'-biphenyl-2-yl)palladium(II); In N,N-dimethyl-formamide; at 120 ℃; for 0.5h; Microwave irradiation;
DOI:10.1021/acs.jmedchem.5b00767

Reference yield:

: 98-09-9
benzenesulfonyl chloride

: 1198803-15-4
N-{5-[4-amino-1-(phenylsulfonyl)-1H-indazol-6-yl]-3-pyridinyl}methanesulfonamide

Guidance literature:: Multi-step reaction with 3 steps

1.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 0.5 h / Cooling with ice

1.2: 0.25 h / 20 °C

1.3: 20 °C

2.1: triethylamine / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / toluene / 1 h / 120 °C / microwave irradiation

3.1: 2’-(dimethylamino)-2-biphenylyl-palladium(II)chloride dinorbornylphosphine complex / N,N-dimethyl-formamide / 0.5 h / 120 °C / microwave irradiation

With sodium hydride; triethylamine; tetrakis(triphenylphosphine) palladium⁽⁰⁾; 2’-(dimethylamino)-2-biphenylyl-palladium(II)chloride dinorbornylphosphine complex; In N,N-dimethyl-formamide; toluene; mineral oil;

Reference yield:

: 885518-50-3
6-bromo-1H-indazole-4-amine

: 1198803-15-4
N-{5-[4-amino-1-(phenylsulfonyl)-1H-indazol-6-yl]-3-pyridinyl}methanesulfonamide

Guidance literature:: Multi-step reaction with 3 steps

1.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 0.5 h / Cooling with ice

1.2: 0.25 h / 20 °C

1.3: 20 °C

2.1: triethylamine / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / toluene / 1 h / 120 °C / microwave irradiation

3.1: 2’-(dimethylamino)-2-biphenylyl-palladium(II)chloride dinorbornylphosphine complex / N,N-dimethyl-formamide / 0.5 h / 120 °C / microwave irradiation

With sodium hydride; triethylamine; tetrakis(triphenylphosphine) palladium⁽⁰⁾; 2’-(dimethylamino)-2-biphenylyl-palladium(II)chloride dinorbornylphosphine complex; In N,N-dimethyl-formamide; toluene; mineral oil;