(E)-N-tert-Butoxycarbonyloxy-(3-{3-[5-methyl-2-(4-trifluoromethyl-phenyl)-oxazol-4-ylmethoxy]-phenyl}-pent-2-enyl)-carbamic acid tert-butyl ester

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Chemical Name:(E)-N-tert-Butoxycarbonyloxy-(3-{3-[5-methyl-2-(4-trifluoromethyl-phenyl)-oxazol-4-ylmethoxy]-phenyl}-pent-2-enyl)-carbamic acid tert-butyl ester
CAS No.:174258-44-7
Molecular Formula:C₃₃H₃₉F₃N₂O₇
Molecular Weight:632.677
Hs Code.:

Synonyms:(E)-N-tert-Butoxycarbonyloxy-(3-{3-[5-methyl-2-(4-trifluoromethyl-phenyl)-oxazol-4-ylmethoxy]-phenyl}-pent-2-enyl)-carbamic acid tert-butyl ester

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Chemical Property of (E)-N-tert-Butoxycarbonyloxy-(3-{3-[5-methyl-2-(4-trifluoromethyl-phenyl)-oxazol-4-ylmethoxy]-phenyl}-pent-2-enyl)-carbamic acid tert-butyl ester

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Technology Process of (E)-N-tert-Butoxycarbonyloxy-(3-{3-[5-methyl-2-(4-trifluoromethyl-phenyl)-oxazol-4-ylmethoxy]-phenyl}-pent-2-enyl)-carbamic acid tert-butyl ester

There total 9 articles about (E)-N-tert-Butoxycarbonyloxy-(3-{3-[5-methyl-2-(4-trifluoromethyl-phenyl)-oxazol-4-ylmethoxy]-phenyl}-pent-2-enyl)-carbamic acid tert-butyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 85006-25-3
N,N-di(tert-butoxycarbonyl)hydroxylamine

: 174258-43-6
(E)-3-{3-[5-methyl-2-(4-trifluoromethyl-phenyl)-oxazol-4-ylmethoxy]-phenyl}-pent-2-en-1-ol

: 174258-44-7
(E)-N-tert-Butoxycarbonyloxy-(3-{3-[5-methyl-2-(4-trifluoromethyl-phenyl)-oxazol-4-ylmethoxy]-phenyl}-pent-2-enyl)-carbamic acid tert-butyl ester

Guidance literature:: With triphenylphosphine; diethylazodicarboxylate; In tetrahydrofuran; at 0 ℃; for 1h;
DOI:10.1021/jm990476x

Reference yield:

: 455-19-6
4-Trifluoromethylbenzaldehyde

: 174258-44-7
(E)-N-tert-Butoxycarbonyloxy-(3-{3-[5-methyl-2-(4-trifluoromethyl-phenyl)-oxazol-4-ylmethoxy]-phenyl}-pent-2-enyl)-carbamic acid tert-butyl ester

Guidance literature:: Multi-step reaction with 8 steps

1.1: 65 percent / HCl gas / ethyl acetate / 3 h / 5 °C

2.1: 30 percent / POCl₃ / CHCl₃ / 2.5 h / Heating

3.1: 65 percent / K₂CO₃ / dimethylformamide / 3 h / 80 °C

4.1: tetrahydrofuran / 0.5 h / 0 °C

5.1: Jones reagent / acetone / 0.5 h / 5 °C

6.1: NaH / toluene / 1 h

6.2: toluene; tetrahydrofuran / 48 h

7.1: DIBAL / diethyl ether / 0.5 h / -78 °C

8.1: diethyl azodicarboxylate; Ph₃P / tetrahydrofuran / 1 h / 0 °C

With hydrogenchloride; jones reagent; sodium hydride; diisobutylaluminium hydride; potassium carbonate; triphenylphosphine; diethylazodicarboxylate; trichlorophosphate; In tetrahydrofuran; diethyl ether; chloroform; ethyl acetate; N,N-dimethyl-formamide; acetone; toluene; 1.1: Condensation / 2.1: Chlorination / 3.1: Alkylation / 4.1: Grignard reaction / 5.1: Oxidation / 6.1: Metallation / 6.2: Condensation / 7.1: Reduction / 8.1: Condensation;
DOI:10.1021/jm990476x

Reference yield:

: 100-83-4
meta-hydroxybenzaldehyde

: 174258-44-7
(E)-N-tert-Butoxycarbonyloxy-(3-{3-[5-methyl-2-(4-trifluoromethyl-phenyl)-oxazol-4-ylmethoxy]-phenyl}-pent-2-enyl)-carbamic acid tert-butyl ester

Guidance literature:: Multi-step reaction with 6 steps

1.1: 65 percent / K₂CO₃ / dimethylformamide / 3 h / 80 °C

2.1: tetrahydrofuran / 0.5 h / 0 °C

3.1: Jones reagent / acetone / 0.5 h / 5 °C

4.1: NaH / toluene / 1 h

4.2: toluene; tetrahydrofuran / 48 h

5.1: DIBAL / diethyl ether / 0.5 h / -78 °C

6.1: diethyl azodicarboxylate; Ph₃P / tetrahydrofuran / 1 h / 0 °C

With jones reagent; sodium hydride; diisobutylaluminium hydride; potassium carbonate; triphenylphosphine; diethylazodicarboxylate; In tetrahydrofuran; diethyl ether; N,N-dimethyl-formamide; acetone; toluene; 1.1: Alkylation / 2.1: Grignard reaction / 3.1: Oxidation / 4.1: Metallation / 4.2: Condensation / 5.1: Reduction / 6.1: Condensation;
DOI:10.1021/jm990476x