2S-[(4'-trifluoromethyl-biphenyl-3-ylmethyl)-carbamoyl]-pyrrolidine-1-carboxylic acid tert-butyl ester

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Chemical Name:2S-[(4'-trifluoromethyl-biphenyl-3-ylmethyl)-carbamoyl]-pyrrolidine-1-carboxylic acid tert-butyl ester
CAS No.:1257437-16-3
Molecular Formula:C₂₄H₂₇F₃N₂O₃
Molecular Weight:448.485
Hs Code.:

Synonyms:2S-[(4'-trifluoromethyl-biphenyl-3-ylmethyl)-carbamoyl]-pyrrolidine-1-carboxylic acid tert-butyl ester

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Chemical Property of 2S-[(4'-trifluoromethyl-biphenyl-3-ylmethyl)-carbamoyl]-pyrrolidine-1-carboxylic acid tert-butyl ester

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Technology Process of 2S-[(4'-trifluoromethyl-biphenyl-3-ylmethyl)-carbamoyl]-pyrrolidine-1-carboxylic acid tert-butyl ester

There total 1 articles about 2S-[(4'-trifluoromethyl-biphenyl-3-ylmethyl)-carbamoyl]-pyrrolidine-1-carboxylic acid tert-butyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 54.0%

: 15761-39-4,59433-50-0
1-(tert-butoxycarbonyl)-L-proline

: 472964-40-2
[3-[4-(trifluoromethyl)phenyl] phenyl]methanamine

: 1257437-16-3
2S-[(4'-trifluoromethyl-biphenyl-3-ylmethyl)-carbamoyl]-pyrrolidine-1-carboxylic acid tert-butyl ester

Guidance literature:: 1-(tert-butoxycarbonyl)-L-proline; With O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; triethylamine; In dichloromethane; at 0 ℃; for 0.5h;

[3-[4-(trifluoromethyl)phenyl] phenyl]methanamine; In dichloromethane; at 0 - 20 ℃; for 8h;

Reference yield: 80.0%

: 349-88-2
4-Fluorobenzenesulfonyl chloride

: 1257437-16-3
2S-[(4'-trifluoromethyl-biphenyl-3-ylmethyl)-carbamoyl]-pyrrolidine-1-carboxylic acid tert-butyl ester

: 1-(5-fluorobenzenesulfonyl)-pyrrolidine-2S-carboxylic acid (4'-trifluoromethylbiphenyl-3-ylmethyl)-amide

Guidance literature:: 2S-[(4'-trifluoromethyl-biphenyl-3-ylmethyl)-carbamoyl]-pyrrolidine-1-carboxylic acid tert-butyl ester; With hydrogenchloride; In 1,4-dioxane; dichloromethane; at 20 ℃; for 3h;

4-Fluorobenzenesulfonyl chloride; With triethylamine; dmap; In dichloromethane; for 12h;